Hypertonic saline resuscitation protects against kidney injury induced by severe burns in rats.

Background: Proper fluid resuscitation can relieve visceral damage and improve survival in severely burned patients. This study compared the effectiveness of resuscitation with 400mEq/L hypertonic saline (HS) and sodium lactate Ringer's solution (LR) in rats with kidney injury caused by burn trauma.

Methods: Rats (Sprague-Dawley) underwent burn injury and were randomized into sham, LR, and HS groups.