Study on the safety and effectiveness of low-dose vs. regular-dose fondaparinux in preventing venous thromboembolism prophylaxis following total knee arthroplasty.

Background: This study aims to evaluate the effectiveness and safety of low-dose (1.5 mg) fondaparinux for venous thromboembolism (VTE) prophylaxis in patients post-total knee arthroplasty (TKA).

Methods: We retrospectively identified 314 patients who carried out the primary TKAs and received fondaparinux for VTE chemoprophylaxis between July 2020 and December 2021.

(E)-4-Hydr-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide.

The mol-ecule of the title compound, C(14)H(11)N(3)O(4), is approximately planar, the dihedral angle between the planes of the two substituted benzene rings being 2.54 (7)°. The mol-ecule exists in a trans configuration with respect to the central methyl-idene unit.

(E)-N'-(4-Hydroxy-benzyl-idene)-4-hydroxy-benzohydrazide methanol solvate.

The title compound, C(14)H(12)N(2)O(3)·CH(4)O, consists of a Schiff base mol-ecule and a methanol mol-ecule of crystallization. The Schiff base mol-ecule is nearly planar, the dihedral angle between the planes of the two benzene rings being 7.2 (2)°.

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-3-methoxy-benzohydrazide.

In the title compound, C(16)H(15)BrN(2)O(3), there are two independent mol-ecules (A and B) in the asymmetric unit. The major difference between the two mol-ecules is the dihedral angle formed by the aromatic rings [72.6 (2) and 18.

(E)-N'-[1-(2-Hydroxy-phen-yl)ethyl-idene]-3-methoxy-benzohydrazide.

In the title compound, C(16)H(16)N(2)O(3), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 26.9 (2)°.

(E)-2-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide.

In the title compound, C(15)H(13)N(3)O(4), the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two benzene rings is 6.8 (2)°.

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide.

In the title compound, C(16)H(15)BrN(2)O(3), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 75.6 (2)°.

(E)-N'-(2-Chloro-5-nitro-benzyl-idene)-4-methoxy-benzohydrazide.

In the title compound, C(15)H(12)ClN(3)O(4), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 0.4 (3)°.