Publications by authors named "Cong-Min Huo"
Int J Biol Macromol
August 2024
Article Synopsis
- * Using lignin nanoparticles (LNPs) can help block the mononuclear phagocyte system (MPS), leading to improved tumor targeting, especially at higher doses (300 mg/kg).
- * While LNPs can penetrate tumors quickly when engineered, they still accumulate in the liver, suggesting that overcoming this capture can enhance drug delivery for effective treatment.
Adv Healthc Mater
April 2024
Article Synopsis
- Researchers developed thulium oxide nanoparticles (TmO) coated with a cancer-thylakoid hybrid membrane to enhance photodynamic therapy (PDT) by generating reactive oxygen species (ROS) and supplying oxygen in tumor hypoxia conditions.
- TmO acts as an effective type II photosensitizer that produces ROS when exposed to near-infrared light, while the thylakoid membrane mimics catalase to convert hydrogen peroxide into oxygen and also generates lethal ROS.
- The study's results demonstrate that tumors treated with this hybrid approach experienced significant ablation after dual-stage light irradiation, showcasing the potential of using rare-earth element photosensitizers in cancer treatments.
