Nervione, a new benzofuran derivative from .

A new benzofuran derivative, nervione (), was isolated from (Blume) Schltr. (Orchidaceae). Eight previously reported compounds were also isolated: 5,7-dimethoxyflavone (2), 3,5,7-trimethoxyflavone (3), 7-methoxyflavone (4), 3,7-dimethoxy-5-hydroxyflavone (5), tetramethylscutellarein (4',5,6,7-tetramethoxyflavone) (6), 5,7-dimethoxy-4'-hydroxyflavone (7), rhamnetin (8), and 5,7-dihydroxy-3',4'-dimethoxyflavone (9).

Flavones from Growing in Vietnam and Their Alpha-Glucosidase Inhibitory Activity.

Kurz is widely used in folk medicine in Eastern Asia and is associated with various ethnopharmacological properties including hepatoprotective, antipyretic, analgesic, antidysenteric, and anthelmintic activities. Previous phytochemical investigations reported the presence of numerous triterpenes (mostly cycloartanes, ursanes, lupanes, and oleananes) along with dozens of flavonoids. However, the extracts of and isolated flavonoids have not been evaluated for their alpha-glucosidase inhibition.

Alpha-Glucosidase Inhibitory Diterpenes from Growing in Vietnam.

Bioactive-guided phytochemical investigation of L. growing in Vietnam led to the isolation of five -atisanes, one --atisane, and one lathyrane (ingol-type). The structures were elucidated as -131617-tetrahydroxyatisane (), ethyl -3,4--4,16,17-trihydroxyatisane-3-carboxylate (), -atisane-3-oxo-16,17-acetonide (), -3-acetoxy-16,17-dihydroxyatisane (), -16,17-dihydroxyatisane-3-one (), calliterpenone (), and ingol 12-acetate ().

Parmosidone K, a new -depsidone from the lichen .

Further phytochemical investigation on led to one new -depsidone, parmosidone K together with one known compound, barbatic acid. Their structures were determined by 1D and 2D NMR analysis, high resolution mass spectroscopy, and comparison their NMR data with those reported in literatures. Parmosidone K was evaluated for α-glucosidase inhibition and revealed the powerful activity with IC value of 3.

Nervisides I-J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from .

Two new cycloartane glycosides, nervisides I-J, were isolated from whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score.

Cytotoxic activity and phytochemical composition of V.S. Dang leaves.

For the first time, the cytotoxic and phytochemical investigation of the leaves of V.S. Dang, a new species discovered in Viet Nam were finalized and led to purify nine compounds, including one furancoumarin , one chromone , two triterpenoids , two flavonoids , , two flavanoids and one iridoid using various chromatography methods.

Markhasphingolipid A, new phytosphingolipid from the leaves of var. V.S. Dang.

From the leaves of var. V.S.

Polysciosides J and K, two new oleanane-type triterpenoid saponins from the leaves of (L.) harms. cultivating in An Giang Province, Viet Nam.

For the first time, the phytochemical constituents of the leaves of (L.) Harms. cultivating in An Giang Province, Viet Nam were investigated and led to purify two new oleanane-type triterpenoid saponins, named polyscioside J () and polyscioside K () together with two known saponins, ladyginoside A () and chikusetsusaponin IVa () using variously chromatographic methods.

Markhacanasin C, cycloartane triterpenoid from the leaves of Markhamia stipulata var. canaense V.S. Dang.

One new cycloartane triterpenoid, named markhacanasin C (1), together with three known triterpenoids, oleanolic acid (2), ursolic acid (3) and 6β,19α-dihydroxyursolic acid (4) were isolated by various chromatographic methods from the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S.

Flavonoids with hepatoprotective activity from the leaves of Cleome viscosa L.

One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rhamnopyranoside (5), kaempferol 7-O-α-l-rhamnopyranoside (6), kaempferitrin (7) and kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (8) were isolated by various chromatography methods from the leaves of Cleome viscosa L. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR (1D & 2D) experiments. The cytotoxicity and hepatoprotective activities using HepG2 human hepatoma cell line of 1 were measured by MTT assay.