Identification and Functional Characterization of a Low-Density Lipoprotein Receptor Gene Pathogenic Variant in Familial Hypercholesterolemia.

We report a single-point variant of low-density lipoprotein receptor () in a Chinese proband with a clinical diagnosis of familial hypercholesterolemia (FH) with a comprehensive functional analysis. Target exome capture-based next-generation sequencing was used for sequencing and identification of genomic variants in the gene. The expression, cellular location, and function of the mutant LDLR were analyzed.

[Effects of clipping on nitrogen allocation strategy and compensatory growth of Leymus chinensis under saline-alkali conditions].

Soil salinization and overgrazing are two main factors limiting animal husbandry in the Songnen Grassland. Leymus chinensis is a dominant rhizome grass, resistant to grazing as well as to-lerant to salt stress. Foliar labeled with N-urea was used to study the nitrogen allocation strategy and compensatory growth response to clipping under saline-alkali conditions.