Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis.

Insulin resistance was considered to be the most important clinical phenotype of type 2 diabetes (T2DM). Almond is a widely-consumed nut and long-term intake was beneficial to alleviating insulin resistance in patients with T2DM. Hence, screening of anti-diabetic peptides from almond proteins was feasible based on the effectiveness of peptides in the treatment of T2DM.

Establishment and validation of predictive model of ARDS in critically ill patients.

Background: Acute respiratory distress syndrome (ARDS) is a prevalent complication among critically ill patients, constituting around 10% of intensive care unit (ICU) admissions and mortality rates ranging from 35 to 46%. Hence, early recognition and prediction of ARDS are crucial for the timely administration of targeted treatment. However, ARDS is frequently underdiagnosed or delayed, and its heterogeneity diminishes the clinical utility of ARDS biomarkers.

Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut-Ovary Axis.

The diverse and dynamic population of microorganisms present in the gut microbiota may affect host health. There are evidences to support the role of gut microbiota as a key player in reproductive development. Unfortunately, the relationship between reproductive disorders caused by aging and gut microbiota remains largely unknown.

Identification of lesion location and discrimination between benign and malignant findings in thyroid ultrasound imaging.

Thyroid nodules are a common thyroid disorder, and ultrasound imaging, as the primary diagnostic tool, is susceptible to variations based on the physician's experience, leading to misdiagnosis. This paper constructs an end-to-end thyroid nodule detection framework based on YOLOv8, enabling automatic detection and classification of nodules by extracting grayscale and elastic features from ultrasound images. First, an attention-weighted DCN is introduced to enhance superficial feature extraction and capture local information.

Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 Edition).

The Chinese Guidelines for Ultrasound-guided Thermal Ablation of Thyroid Nodules (2024 edition) were jointly initiated by the Ultrasound Committee of Chinese Medical Association, the Interventional Ultrasound Committee of Chinese Association of Ultrasound in Medicine and Engineering, the Ultrasonic Intervention Committee of Chinese Colleges of Interventionalists, the Oncological Intervention Committee of Chinese Research Hospital Association, 37 multidisciplinary experts in interventional ultrasound, ultrasound medicine, endocrinology and thyroid surgery participated in the compilation of this guide, which expanded the depth and breadth of the perspective and enhanced the authority of the guide. Based on the systematic review of literatures related to ultrasound-guided thermal ablation of thyroid nodules and the professional opinions of experts, the guidelines define the indications and contraindications of thermal ablation, including pre-ablation evaluation and preparation, thermal ablation techniques and operational procedures, post-ablation follow-up, therapeutic effect evaluation, complications prevention and treatment, and the writing of medical documents for ablation. According to the Grading of Recommendations Assessment, Development and Evaluation (GRADE), a total of 17 objective and comprehensive recommendations were given.

Silencing LY6K Suppresses CD44 EpCAM HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence.

Lymphocyte antigen 6 complex, locus K (LY6K) is a putative oncogene in various human cancers, including colorectal cancer, where elevated expression is associated with poor prognosis. This study investigates the antitumor effects of LY6K in colon cancer stem cells (CCSCs) both in vitro and in vivo. EpCAM and CD44 surface markers were used to isolate CCSCs from HCT116 cells, and the expression of LY6K in CCSCs was analyzed by real-time PCR.

High-Efficiency Fluorescent-Coupled Optical Fiber Passive Tactile Sensor with Integrated Microlens for Surface Texture and Roughness Detection.

Integrating ZnS:Cu@AlO/polydimethylsiloxane (PDMS) flexible matrices with optical fibers is crucial for the development of practical passive sensors. However, the fluorescence coupling efficiency is constrained by the small numerical aperture of the fiber, leading to a reduction in sensor sensitivity. To mitigate this limitation, a microsphere lens was fabricated at the end of the multimode fiber, which resulted in a 21.

Estimating the incremental population health impact of a multi-cancer early detection (MCED) test to complement existing screening among elevated risk populations with multiple cancer risk factors: a mathematical modeling study.

Background: The added benefits of a multi-cancer early detection (MCED) test among individuals with multiple risk factors will help policy decision-makers allocate limited healthcare resources. This study sought to estimate the population health implications of adding an MCED test to standard-of-care (SOC) cancer screening tests among individuals aged 50-79 years with additional cancer risk factors (i.e.

EIF4A3-Induced hsa_circ_0118578 Expression Enhances the Tumorigenesis of Papillary Thyroid Cancer.

Circular RNA (circRNA) plays a regulatory role in the malignancy of papillary thyroid cancer (PTC). However, the role of a novel circRNA, hsa_circ_0118578, in PTC is not yet fully understood. This report focuses on unveiling hsa_circ_0118578's effect on PTC cell malignancy and reveals its mechanism in PTC progression.

Diverse N-Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual-Functional Small Molecule.

Amine oxidation is an important organic reaction for the production of high-value N-containing compounds. However, it is still challenging to control the reactivity of active N-centered radicals to selectively access N-oxidation products. Herein, this study reports the engineering of cytochrome P450BM3 into multifunctional N-oxidizing enzymes with the assistance of dual-functional small molecules (DFSM) to selectively produce N-oxygenation (i.

Magnetic-Powered Spora Lygodii Microrobots Loaded with Doxorubicin for Active and Targeted Therapy of Bladder Cancer.

Background And Purpose: Bladder cancer has high recurrence rates despite standard treatments, necessitating innovative therapeutic approaches. This study introduces magnetically powered microrobots utilizing Traditional Chinese Medicine (TCM) Spora Lygodii (SL) encapsulated with Doxorubicin (DOX) and FeO nanoparticles (Fe/DOX@SL) for targeted therapy.

Methods: FeO nanoparticles were synthesized via co-precipitation and combined with SL spores and DOX through dip-coating to form Fe/DOX@SL microrobots.

A penta-component mpox mRNA vaccine induces protective immunity in nonhuman primates.

The recent worldwide outbreaks of mpox prioritize the development of a safe and effective mRNA vaccine. The contemporary mpox virus (MPXV) exhibits changing virological and epidemiological features, notably affecting populations already vulnerable to human immunodeficiency virus (HIV). Herein, we profile the immunogenicity of AR-MPXV5, a penta-component mRNA vaccine targeting five specific proteins (M1R, E8L, A29L, A35R, and B6R) from the representative contemporary MPXV clade II strain, in both naive and simian immunodeficiency virus (SIV)-infected nonhuman primates.

NPtagM: A Tailoring Enzyme Genome Mining Toolkit and Its Application in Terpenoid P450s from Phytopathogenic Fungi.

Terpenoids derived from phytopathogenic fungi are major participants in interactions among microorganisms, plants, and animals. The modifications catalyzed by cytochrome P450s significantly influence the structural and bioactivity diversity of the terpenoids. To conduct genome mining of P450s in pathogenic fungi, in this study, we developed a new software called atural roducts iloring Enzymes enome ining (NPtagM).

Analysis of factors affecting subjective cognitive decline in elderly hypertensive patients and the construction of a risk prediction model.

Subjective cognitive decline (SCD) is more prevalent in the elderly Chinese population, and individuals with hypertension are at greater risk for cognitive impairment. The aim of this study was to investigate the prevalence and factors affecting SCD in elderly hypertensive patients and to develop a risk prediction model. This was a cross-sectional study of 1098 elderly hypertensive patients in a tertiary care hospital.

The study on ultrasound image classification using a dual-branch model based on Resnet50 guided by U-net segmentation results.

In recent years, the incidence of nodular thyroid diseases has been increasing annually. Ultrasonography has become a routine diagnostic tool for thyroid nodules due to its high real-time capabilities and low invasiveness. However, thyroid images obtained from current ultrasound tests often have low resolution and are plagued by significant noise interference.

Genome-wide pan-GPCR cell libraries accelerate drug discovery.

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful drug targets. However, only approximately 15% of the 800 human GPCRs are targeted by market drugs, leaving numerous opportunities for drug discovery among the remaining receptors.

Efficient single-frequency Tm:YAG crystal-derived silica fiber laser at 1.7 µm.

A single-frequency distributed Bragg reflector (DBR) fiber laser operating at 1720 nm has been demonstrated for the first time using a Tm:YAG crystal-derived silica fiber (TCDSF), to the best of our knowledge. A single-frequency laser with an over 220 mW output power was achieved from a 1.5-cm-long TCDSF when being in-band pumped by a homemade 1610 nm fiber laser.

TLR3 activation mediates partial epithelial-to-mesenchymal transition in human keratinocytes.

TLR3 is expressed in human skin and keratinocytes, and given its varied role in skin inflammation, development, and regeneration, we sought to determine the cellular response in normal human keratinocytes to TLR3 activation. We investigated this mechanism by treating primary human keratinocytes with both UVB, an endogenous and physiologic TLR3 activator, and poly(I:C), a synthetic and selective TLR3 ligand. TLR3 activation with either UVB or poly(I:C) altered keratinocyte morphology, coinciding with the key features of epithelial-to-mesenchymal transition: increased epithelial-to-mesenchymal transition gene expression, enhanced migration, and increased invasion properties.

Mechanoluminescence of ZnS: Cu@AlO enabled optical fiber microlens passive tactile sensor for hardness recognition.

We propose an optical fiber microlens (OFM) passive tactile sensor (OFMPTS) for hardness recognition. The sensor features a core-shell structure, with an OFM as the core and an elastic mechanoluminescence (ML) matrix shell, which is composed of ZnS: Cu@AlO doped with 10 nm SiO particles and polydimethylsiloxane (PDMS). Utilizing the Hertz model, the ML intensity of the sensor is correlated to the elastic modulus of the sample, which enables precise hardness detection.

Identification and evaluation of deep foundation pit construction risks based on Grey-DEMATEL-Fuzzy comprehensive evaluation method.

In recent years, foundation pit construction has been rapidly developing in the direction of deep and large-scale, leading to the frequent occurrence of construction accidents. The pit construction process is characterised by a complex environment, high construction risk, and numerous coupling effects between the construction risk factors. In this paper, 23 main accident-causing factors in foundation pit construction are determined based on the six major risk accident types.