[Huanglian Jiedu Decoction prevents and treats acute liver injury in septic mice via AMPK/SIRT1 autophagy pathway].

This study aims to explore the mechanism of Huanglian Jiedu Decoction(HJD) in treating acute liver injury(ALI) in the mouse model of sepsis induced by lipopolysaccharide(LPS). Fifty-four male C57BL/6 mice were randomized into six groups: blank group, model group, low-, medium-, and high-dose group HJD, and dexamethasone group. The mouse model of sepsis was established by intraperitoneal injection of LPS after 7 days of gavage with HJD, and dexamethasone(0.

gen. nov., sp. nov.: a novel species of a novel genus in the family , isolated from the sediment of a tidal flat located in Zhoushan, China.

A Gram-stain-negative, aerobic and rod-shaped bacterium, designated as HZG-20, was isolated from a tidal flat in Zhoushan, Zhejiang Province, China. The 16S rRNA sequence similarities between strain HZG-20 and RR4-56, NNCM2, P31 and X9-2-2 were 98.9, 91.

Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma.

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These molecules significantly influence the cell cycle of tumor cells and control programmed cell death (apoptosis). Currently, research on miRNAs has become a major focus in developing cancer therapies.

Laser-chemical composite manufacturing of biomimetic stepped armor functional metal surface with wear resistance and anti-icing characteristics.

Superhydrophobic surfaces have been demonstrated to exhibit excellent anti-icing effects, but they are susceptible to the loss of ice repellency as a result of external impacts. This paper proposes a novel bionic armour structure that combines an armour structure with an arrowroot bionic structure. A composite method combining laser etching and chemical modification was employed to achieve superhydrophobicity on the surface of the aluminium alloy.

Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization.

Epstein-Barr virus (EBV) is an oncogenic virus associated with multiple lymphoid malignancies and autoimmune diseases. During infection in B cells, EBV uses its major glycoprotein gp350 to recognize the host receptor CR2, initiating viral attachment, a process that has lacked direct structural evidence for decades. In this study, we resolved the structure of the gp350-CR2 complex, elucidated their key interactions, and determined the site-specific N-glycosylation map of gp350.

A comprehensive map of DNA-segment copy number variation in 491 genomes of common wheat uncovers genes associated with multiple agronomic traits.

DNA-segment copy number variations (DSCNVs), such as deletions and duplications, are important sources of genomic structural variation. However, the types and sizes of DSCNVs, as well as their genome-wide distribution and potential functions, are poorly understood in wheat. Here, we identified 198 985 DSCNVs by investigating 491 genomes of common wheat and found that they account for 20% of the entire genome.

A multimodal approach for few-shot biomedical named entity recognition in low-resource languages.

In this study, we revisit named entity recognition (NER) in the biomedical domain from a multimodal perspective, with a particular focus on applications in low-resource languages. Existing research primarily relies on unimodal methods for NER, which limits the potential for capturing diverse information. To address this limitation, we propose a novel method that integrates a cross-modal generation module to transform unimodal data into multimodal data, thereby enabling the use of enriched multimodal information for NER.

Anthropomorphic Design in Mortality Salience Situations: Exploring Emotional and Non-Emotional Mechanisms Enhancing Consumer Purchase Intentions.

This study investigates the role of anthropomorphic design in alleviating consumer anxiety induced by mortality salience and delves into the underlying emotional and non-emotional mechanisms. Through a series of meticulously designed experiments, we confirm that anthropomorphic design significantly enhances positive emotional responses in consumers, reduces negative emotions, and thereby increases their preference and willingness to purchase products. Even after the diminution of emotional reactions, anthropomorphic design continues to sustain consumer preference by enhancing psychological intimacy.

Preparation and properties of edible active films of gelatin/carboxymethyl cellulose loaded with resveratrol.

Resveratrol (Res) powder was incorporated into gelatin (GEL)/carboxymethyl cellulose (CMC) film-forming solutions to create GEL/CMC-Res composite films (G/C-R) without the use of organic solvents. The study focused on how phase separation affected the properties of these films. The film formation mechanism of the G/C-R films was analyzed using infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD).

Research landmarks on the 60th anniversary of Epstein-Barr virus.

Epstein-Barr virus (EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

Complications of Subcision for Acne Scarring: Experience From Clinical Practice and Review of the Literature.

Background: Subcision is a surgical technique frequently used in the management of atrophic acne scars. The advent of new instruments, which includes sharp, blunt and energy assisted, have increased the efficacy of the procedure. The aim of this article was to review the safety of subcision in view of the new development in technology.

Developmental Pattern of Individual Morphometric Similarity Network in the Human Fetal Brain.

The development of the cerebral cortex during the fetal period is a complex yet well-coordinated process. MRI-based morphological brain network provides a powerful tool for describing this process at a network level. Due to the challenges of in-utero MRI acquisition and image processing, the fetal morphological brain network has not been established.

Demonstration-based learning for few-shot biomedical named entity recognition under machine reading comprehension.

Objective: Although deep learning techniques have shown significant achievements, they frequently depend on extensive amounts of hand-labeled data and tend to perform inadequately in few-shot scenarios. The objective of this study is to devise a strategy that can improve the model's capability to recognize biomedical entities in scenarios of few-shot learning.

Methods: By redefining biomedical named entity recognition (BioNER) as a machine reading comprehension (MRC) problem, we propose a demonstration-based learning method to address few-shot BioNER, which involves constructing appropriate task demonstrations.

A framework for human evaluation of large language models in healthcare derived from literature review.

With generative artificial intelligence (GenAI), particularly large language models (LLMs), continuing to make inroads in healthcare, assessing LLMs with human evaluations is essential to assuring safety and effectiveness. This study reviews existing literature on human evaluation methodologies for LLMs in healthcare across various medical specialties and addresses factors such as evaluation dimensions, sample types and sizes, selection, and recruitment of evaluators, frameworks and metrics, evaluation process, and statistical analysis type. Our literature review of 142 studies shows gaps in reliability, generalizability, and applicability of current human evaluation practices.

Coupling and coordination of food security and agricultural carbon emission efficiency: Changing trends, influencing factors, and different government priority scenarios.

Seeking a balance between food security and carbon mitigation is key to achieving sustainable agricultural development. This study evaluates the coupling coordination degree (CCD) between the food security index (FSI) and agricultural carbon emission efficiency (ACEE) in China from 2010 to 2021 using the coupled coordination model. By adjusting the model coefficients, different government priority scenarios are simulated to explore their impact on CCD.

A motion assessment method for reference stack selection in fetal brain MRI reconstruction based on tensor rank approximation.

Slice-to-volume registration and super-resolution reconstruction are commonly used to generate 3D volumes of the fetal brain from 2D stacks of slices acquired in multiple orientations. A critical initial step in this pipeline is to select one stack with the minimum motion among all input stacks as a reference for registration. An accurate and unbiased motion assessment (MA) is thus crucial for successful selection.

Unpacking the Influence of Visual Density on Pizza Packaging: Sensory Expectations and Purchase Intentions.

Visual density, defined as the number of identifiable elements per unit area within a visual design, significantly influences consumer perceptions. This study investigates the effects of varying visual densities in pizza packaging, encompassing both food-related and decorative elements, on consumers' expectations regarding taste and texture, ultimately influencing their purchase decisions. We conducted a controlled experiment where participants were presented with pizza boxes of differing visual densities.

sp. nov. and sp. nov., two novel species isolated from tidal flat sediments.

Two Gram-stain-negative, rod-shaped, non-motile, aerobic and carotenoid-producing strains, belonging to the family designated as H149 and Z2, were isolated from tidal flat sediment samples collected in Hainan and Zhejiang, PR China, respectively. Growth of strain H149 occurred at 15-42 °C, 0-10.0 % (w/v) NaCl, and pH 6.

Coupled coordination and pathway analysis of food security and carbon emission efficiency under climate-smart agriculture orientation.

Owing to the contradiction between agricultural production and environmental development, the issues of food security and carbon mitigation cannot be isolated, and achieving coupled and coordinated development is the key to agricultural sustainability. This study adopted the coupled coordination model and dynamic qualitative comparative analysis (dynamic QCA) method to measure the coupled coordination degree (CCD) of the food security index (FSI) and agricultural carbon emission efficiency (ACEE) in 31 provinces of China from 2010 to 2021, seeking paths to achieve high coupled coordination from Climate-Smart Agriculture technology, external environment, and incentive dimensions, and simulating path selection differences under various CSA priority scenarios. The results indicated that the CCD of the FSI and ACEE in China significantly increased year-on-year increase, with significant regional differences primarily reflected in the Northeast > East > West > Central regions.

A pan-KRAS degrader for the treatment of KRAS-mutant cancers.

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have been advancements in the development of small molecules to target specific KRAS mutants, the presence of undruggable mutants and the emergence of secondary mutations continue to pose challenges in the clinical treatment of KRAS-mutant cancers. In this study, we developed a novel molecular tool called tumor-targeting KRAS degrader (TKD) that effectively targets a wide range of KRAS mutants.

Recurrence Rate of Small Melanoma In Situ on Low-Risk Sites Excised With 5-mm Excisional Margin.

Importance: The incidence of melanoma in situ (MIS) has increased significantly over the past decades, and traditional guidelines for treatment of MIS have been excision with a 5-mm clinical margin; however, current Australian and other guidelines now recommend 5- to 10-mm margins. This changed recommendation was largely driven by the outcomes of studies using Mohs micrographic surgery, and recent studies using Mohs micrographic surgery are advocating for even wider excisions up to 18 mm for clearance.

Objective: To assess the rate of recurrence of MIS excised with a 5-mm margin.