HN1-mediated activation of lipogenesis through Akt-SREBP signaling promotes hepatocellular carcinoma cell proliferation and metastasis.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide, with more than 800,000 deaths each year, and its 5-year survival rate is less than 12%. The role of the HN1 gene in HCC has remained elusive, despite its upregulation in various cancer types. In our investigation, we identified HN1's heightened expression in HCC tissues, which, upon overexpression, fosters cell proliferation, migration, and invasion, unveiling its role as an oncogene in HCC.

Regulation of Hippo-YAP/CTGF signaling by combining an HDAC inhibitor and 5-fluorouracil in gastric cancer cells.

Histone deacetylase (HDAC) inhibitors diminish carcinogenesis, metastasis, and cancer cell proliferation by inducing death in cancer cells. Tissue regeneration and organ development are highly dependent on the Hippo signaling pathway. Targeting the dysregulated hippo pathway is an excellent approach for cancer treatment.

Inhibition of the interaction between Hippo/YAP and Akt signaling with ursolic acid and 3'3-diindolylmethane suppresses esophageal cancer tumorigenesis.

Hippo/YAP signaling hinders cancer progression. Inactivation of this pathway contributes to the development of esophageal cancer by activation of Akt. However, the possible interaction between Akt and Hippo/YAP pathways in esophageal cancer progression is unclear.

3,3'-Diindolylmethane Augments 5-Fluorouracil-InducedGrowth Suppression in Gastric Cancer Cells through Suppression of the Akt/GSK-3 and WNT/Beta-Catenin.

Gastric cancer (GC) is one of the most lethal cancers in South Korea, and it is a cancer of concern worldwide. 5-fluorouracil (5-Fu) is commonly used as the first-line therapy for advanced GC; however, its side effects often limit the dosage range and impair patients' quality of life. Due to the limitations of current chemotherapy, new anticancer therapies are urgently needed.

[Spectroscopic study on the combustion reaction characteristics of methylcyclohexane].

Using a measurement system consisting of monochromators, photomultiplier tubes, piezoelectric pressure sensors and a digital oscilloscope, characteristic emissions of intermediate products OH, CH and C2 produced in the combustion reaction of methylcyclohexane were measured behind reflected shock waves in a shock tube, and ignition delay times of methylcyclohexane/ oxygen/argon were acquired. Experimental conditions cover temperatures from 1 164 to 1 566 K, pressures from 1.03 to 1.

[Measurements of the ignition delay times of n-heptane by using characteristic emission from OH radical].

Using a measurement system consisting of a monochromator, a photomultiplier tube (PMT), piezoelectric pressure sensors and a digital oscilloscope, the ignition delay times of n-heptane/O2 mixture were measured behind reflected shock waves in a chemical shock tube, the onset of ignition was indicated by the steepest rise of the characteristic emission from OH radical at 306.4 nm. The experimental conditions cover temperatures from 1 170 to 1 730 K, pressures at (1.