Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4.

Background: Syringin (SRG) is well-known for its anti-inflammatory effects. However, its pharmacological mechanisms against rheumatoid arthritis (RA) are not fully understood.

Materials And Methods: We assessed the anti-RA effects of SRG using a collagen-induced arthritis (CIA) rat model.

Electrochromism via reversible electrodeposition of solid iodine.

Electrochromic materials were discovered in the 1960s when scientists observed reversible changes between the light and dark states in WO thin films under different voltages. Since then, researchers have identified various electrochromic material systems, including transition metal oxides, polymer materials, and small molecules. However, the electrochromic phenomenon has rarely been observed in non-metallic elemental substances.

Ubiquitin specific peptidase 11 knockdown slows Huntington's disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway.

Background: Mitochondrial dysfunction and neuronal damage are major sign of cytopathology in Huntington's disease (HD), a neurodegenerative disease. Ubiquitin specific peptidase 11 (USP11) is a deubiquitinating enzyme involved in various physiological processes through regulating protein degradation. However, its specific role in HD is unclear.

Molecular Ferroelectrics for Highly Sensitive Detection Toward Low-Frequency Sound Recognition.

Human hearing cannot sensitively detect sounds below 100 Hz, which can affect the physical well-being and lead to dizziness, headaches, and nausea. Piezoelectric acoustic sensors still lack sensitivity to low-frequency sounds owing to the low piezoelectric coefficient or high elastic modulus of materials. The low elastic modulus and substantial piezoelectric coefficient of molecular ferroelectric materials make them excellent candidates for acoustic sensors.

FOXL2 Knockdown Inhibits the Progression of Endometriosis.

Problem: Endometriosis (EM) is known as a common estrogen-dependent chronic inflammatory disease. Elevated levels of Forkhead box L2 (FOXL2) have been observed in uterine diseases, including EM. However, the molecular mechanism of FOXL2 in EM needs to be further illustrated.

Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity.

Pseudomonas syringae deploys a type III secretion system (T3SS) to deliver effector proteins to facilitate infection of plant cells; however, little is known about the direct interactions between T3SS components and plants. Here, we show that the specialized lytic transglycosylase (SLT) domain of P. syringae pv.

Effect of Aconitum diphtheria on the Proliferation, Apoptosis, and Inflammatory Response of Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Rheumatoid arthritis (RA), a highly disabling autoimmune disease, is characterized by joint damage and synovial hyperplasia. This paper was designed to explore the effect and mechanisms of Aconitum diphtheria on the proliferation and apoptosis of RA fibroblast-like synoviocytes (RA-FLS). First, RA-FLS was treated with different doses of A.

[Prevalence and influencing factors of severe respiratory infections in childhood among residents of China, 2019-2020].

To analyze the exposure level and changes in severe respiratory infection among Chinese residents aged ≥40 years in China and to provide essential data for preventing and controlling chronic respiratory diseases. The data came from chronic obstructive pulmonary disease surveillance of Chinese residents in 2014-2015 and 2019-2020. The surveillance covers 31 provinces (autonomous regions and municipalities) in China.

Robust MnO-WO Complementary Electrochromic Device Enabled by Reversible Electrodeposition of MnO.

Reversible electrodeposition and dissolution of manganese oxide (MnO) represent an emerging electrochromic system. However, challenges such as "dead MnO" formation, limited optical modulation across a narrow wavelength range, and difficulties in scaling up have significantly hindered the development of MnO reversible electrodeposition-based electrochromic windows. In this work, we introduced Fe/Fe mediator ions into the electrolyte to suppress the Jahn-Teller effect, thereby preventing the formation of "dead MnO" and achieving stable and reversible MnO deposition/dissolution.

Hierarchical transformer speech depression detection model research based on Dynamic window and Attention merge.

Depression Detection of Speech is widely applied due to its ease of acquisition and imbuing with emotion. However, there exist challenges in effectively segmenting and integrating depressed speech segments. Multiple merges can also lead to blurred original information.

Neuroticism trait and postnatal depression among Chinese women: the mediating role of childbirth experience and the moderating role of perceived social support.

Background: Despite the link between neuroticism trait and postnatal depression has been confirmed, little is known about the factors that influence this association. This study aimed to examine whether childbirth experience mediated the association between neuroticism trait and postnatal depression, and whether this indirect effect was moderated by perceived social support.

Methods: A cross-sectional study was conducted with 1686 women within one year postpartum from 38 hospitals in China.

Effectiveness of smartphone-based music intervention on perinatal depression: protocol for a randomized controlled trial.

Background: Perinatal depression has become a global public health issue with a high prevalence rate. Multiple studies have confirmed the effectiveness of music intervention. Still, the current form of offline intervention ignores issues such as convenient transportation and the stigma of diseases that pregnant women are concerned about, resulting in poor adherence.

Rate and Change in Household Solid Fuels Usage Among Residents Aged 40 and Older - China, from 2014-2015 to 2019-2020.

Introduction: Solid fuel combustion is a significant source of household air pollution and an important risk factor for chronic obstructive pulmonary disease (COPD). This study presents the rates and change in the use of solid fuels for cooking and heating in China.

Methods: Based on data from the Chinese Chronic Obstructive Pulmonary Disease Surveillance, the research estimated the rates and change of solid fuels usage for cooking and heating from 2014-2015 to 2019-2020 and the rate of primary cooking solid fuels usage in 2019-2020, and analyzed the association between solid fuels usage and COPD.

Efficacy and safety of immunosuppressants and monoclonal antibodies in adults with myasthenia gravis: a systematic review and network meta-analysis.

Numerous clinical trials for myasthenia gravis (MG) treatment have been conducted recently, with satisfactory cognitive and clinical results. However, due to the limited evidence for direct comparison of the safety and effectiveness of various drugs, there is a need for further exploration of the advantages and disadvantages of different monoclonal antibodies and immunosuppressants. Thus, in the present network meta-analysis (NMA), we aimed to compare the efficacy and safety of immunosuppressants and monoclonal antibodies in treating MG.

Determination of multi-pesticide residues in agricultural products with a modified QuEChERS process based on magnetic biochar from coconut clothing.

In this study, the magnetic biochar material derived from coconut clothing was firstly successfully synthesized by in-situ polymerization method and applied as QuEChERS adsorbents for extracting multi-pesticides. The obtained magnetic coconut-clothing biochar (MCCBC) presented alveolate structure with abundant large irregular pores. The FeO particles was obviously attached on the surface of biochar.

The effect of music intervention on depression in perinatal women: A systematic review.

Objective: Perinatal depression has become a global public health problem, which not only harms the health of mothers and their offspring, but also increases the socio-economic burden, so early intervention is urgent. Music intervention is a low-cost and safe intervention method. This study endeavored to systematically integrate and quantitatively evaluate the effectiveness of music intervention for perinatal depression.

Single ambipolar OECT-based inverter with volatility and nonvolatility on demand.

Organic electrochemical transistor (OECT)-based inverter introduces new prospects for energy-efficient brain-inspired artificial intelligence devices. Here, we report single-component OECT-based inverters by incorporating ambipolar p(gDPP-V). Notably, p(gDPP-V) shows state-of-the-art ambipolar OECT performances in both conventional (p/n-type mode transconductance of 29/25 S cm) and vertical (transconductance of 297.

FederEI: Federated Library Matching Framework for Electron Ionization Mass Spectrum Based Compound Identification.

Mass spectrometry (MS) is a powerful tool for compound structure elucidation, crucial in various domains including pharmaceuticals, chemical synthesis, environmental analysis, and metabolomics. Compound identification via spectral matching relies heavily on reference libraries, yet existing universal libraries may lack comprehensiveness. Laboratories often create their own libraries, leading to fragmentation within the scientific community.

The influence of spin-spin interaction on high partial wave Feshbach resonance in ultracold 23Na -87Rb system.

In this paper, we investigate the Feshbach resonances of high partial waves and the influence of spin-spin (S-S) interaction on ultracold scattering processes. Taking the Na23- Rb87 system as an example, we plot the variations of weakly bound state energy and elastic scattering cross section with magnetic field and with collision energy. We find that the number of splittings in high partial wave Feshbach resonances does not strictly conform to the expected l + 1 (l is rotational angular momentum), and the deviation is attributed to the influence of bound states in other channels coupled by S-S interaction.

Designing electrolytes with high solubility of sulfides/disulfides for high-energy-density and low-cost K-Na/S batteries.

Alkaline metal sulfur (AMS) batteries offer a promising solution for grid-level energy storage due to their low cost and long cycle life. However, the formation of solid compounds such as MS and MS (M = Na, K) during cycling limits their performance. Here we unveil intermediate-temperature K-Na/S batteries utilizing advanced electrolytes that dissolve all polysulfides and sulfides (KS, x = 1-8), significantly enhancing reaction kinetics, specific capacity, and energy density.