Publications by authors named "Cong Ming-Hua"
Article Synopsis
- - The study aims to explore the relationship between sarcopenia (muscle loss) and outcomes in patients with extensive small-cell lung cancer (SCLC) treated with first-line immunochemotherapy, involving 63 patients over a two-year period.
- - Results showed that 19% of the patients had sarcopenia, which was linked to older age, lower BMI, reduced grip strength, and lower albumin levels, as well as a poorer response to treatment (30% vs. 79% response rate).
- - Overall survival was significantly shorter for patients with sarcopenia, averaging 9 months compared to 24 months for those without sarcopenia, despite similar rates of chemotherapy-related side effects.
Article Synopsis
- This study investigated the calf proportion index (CPI) to assess its relationship with malnutrition and survival in overweight and obese cancer patients.
- The research included 3,499 patients and found that lower CPI values were correlated with higher mortality and greater risk of malnutrition, especially in obese individuals.
- The CPI proved to be a more effective predictor of survival than other measurements, and specific cut-off values were identified (0.65% for men, 0.57% for women) to determine risk levels.
Article Synopsis
- Older cancer patients face increased risks of malnutrition and decreased quality of life (QoL), prompting a study on the correlation between malnutrition and QoL using GLIM criteria for diagnosis.
- This study included over 5,300 older cancer patients, revealing that those with malnutrition had lower QoL scores, with severe malnutrition having the most significant impact on QoL.
- The findings indicated that both malnutrition and QoL are critical factors in predicting survival for older cancer patients, particularly for those with lung and gastric cancers.
Article Synopsis
- This study investigated the prognostic value of hepatic proteins (albumin, prealbumin, and transferrin) in predicting survival outcomes for patients with cancer cachexia, a condition marked by severe weight loss and muscle wasting.
- In a cohort of 1,303 patients, low levels of these proteins were associated with higher mortality rates, confirming their role as independent risk factors for long-term survival in various types of cancer.
- The findings highlighted that albumin was the strongest predictor of survival, especially in patients with certain cancers like upper gastrointestinal and colorectal types, emphasizing the importance of monitoring these protein levels in cancer care.
Objectives: To explore the effect of combined hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancer and to screen for the best prognostic indicators.
Introduction: Gastric and colorectal cancer is a widespread health concern worldwide and one of the major contributors to cancer-related death. The hematological and physical measurement indicators have been shown to associate with the prognosis of patients undergoing surgery for gastric or colorectal cancer, respectively, but it is still unclear whether the combination of the two can reflect the prognosis more effectively.
Background: The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI has not been validated in patients with cancer cachexia. Thus, this study aimed to explore the potential clinical value of the CTI in patients with cancer cachexia.
Methods: In this study, our prospective multicenter cohort included 1411 patients with cancer cachexia (mean age 59.
Purpose: Our study aimed to comprehensively analyze the association between anemia and systemic inflammation in older patients with cancer.
Methods: This multicenter prospective cohort study included 4955 older patients with cancer between 2013 and 2020. Logistic regression analysis was performed to investigate risk factors of anemia, reporting odds ratios (ORs), and 95% confidence intervals (CIs).
A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer.
J Cachexia Sarcopenia Muscle
December 2023
Background: Involuntary weight loss and increased systemic response are frequently observed in patients with cancer, especially in advanced stages. This study aimed to develop a powerful weight loss and inflammation grading system (WLAIGS) and investigate its prognostic performance in patients with advanced cancer.
Methods: This multicentre prospective cohort study included 11 423 patients with advanced cancer.
Background: Malnutrition and systemic inflammation are considered 2 hallmarks of cancer cachexia. Our study aimed to construct a modified Controlling Nutritional Status by introducing C-reactive protein as an inflammatory parameter and investigate its prognostic value in patients with cancer cachexia.
Methods: This multicenter cohort study included 5221 patients with cancer, among whom 1719 were diagnosed with cachexia.
Prognostic value of systemic inflammation and for patients with colorectal cancer cachexia.
J Cachexia Sarcopenia Muscle
December 2023
Background: The development and progression of cancer cachexia are connected to systemic inflammation and physical performance. However, few relevant studies have reported the survival outcomes prediction of systemic inflammation and physical performance in patients with colorectal cancer (CRC) cachexia. This study investigated the prognostic prediction value of systemic inflammation and performance status in patients with CRC cachexia.
View Article and Find Full Text PDFBackground: Malnutrition and increased systemic inflammatory responses are highly prevalent in patients with cancer and they have a negative effect on prognosis. We aimed to develop a nutrition-inflammation prognostic grading system (NIPGS) for patients with cancer, which incorporates the Nutritional Risk Screening 2002 (NRS 2002) and C-reactive protein (CRP) levels.
Methods: This multicenter retrospective cohort study totally included 6891 patients diagnosed with cancer.
Article Synopsis
- The study assessed sarcopenia (muscle loss) in a large group of cancer patients and its impact on prognosis, finding that 33% of 13,761 patients had sarcopenia.
- Age was identified as the most significant risk factor for sarcopenia, with those affected experiencing worse nutritional status and quality of life.
- Sarcopenia was linked to higher mortality rates in cancer patients, suggesting it is a critical consideration in managing cancer care.
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.
View Article and Find Full Text PDFPurpose: Previous studies have shown that both hand grip strength (HGS) and the modified Glasgow Prognostic Score (mGPS) are associated with poor clinical outcomes in patients with liver cancer. In spite of this, no relevant studies have been conducted to determine whether the combination of HGS and mGPS can predict the prognosis of patients with liver cancer. Accordingly, this study sought to explore this possibility.
View Article and Find Full Text PDFTo investigate the prognostic value of systemic inflammation and insulin resistance in women with breast cancer with different body mass index (BMI). This multicenter, prospective study included 514 women with breast cancer. Multivariate survival analysis showed that patients with high C-reactive protein (CRP), high CRP to albumin ratio (CAR), high lymphocyte to CRP ratio (LCR), high low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LHR), and high triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) were significantly associated with worse prognosis.
View Article and Find Full Text PDFBackground: Changes in body composition and systemic inflammation are important characteristics of cancer cachexia. This multi-centre retrospective study aimed to explore the prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia.
Methods: The modified advanced lung cancer inflammation index (mALI), which combines body composition and systemic inflammation, was defined as appendicular skeletal muscle index (ASMI) × serum albumin/neutrophil-lymphocyte ratio.
Background: Inflammation is involved in the progression and prognosis of cancer because it can affect the physical status and prognosis of patients. Among numerous systemic inflammatory markers, the optimal prognostic indicator of older adults with cancer is still unclear. We aimed to identify an ideal inflammatory immune marker in older adults with cancer and assess the survival outcome combined with eastern cooperative oncology group performance status (ECOG PS).
View Article and Find Full Text PDFBackground: Elderly patients with cancer face the challenge of systemic inflammation, which can lead to a poor prognosis. Existing inflammatory indices cannot fully reflect the immune-inflammatory status of patients. This study aimed to develop a new scoring system to predict the survival of elderly patients with cancer using inflammatory indices, namely, the systemic inflammation prognostic score (SIPS).
View Article and Find Full Text PDFBackground: Systemic inflammation and insulin resistance (IR) are closely related in patients with cancer. However, there is no relevant indicator that combines inflammation and IR to predict patient prognosis. Therefore, this study aimed to develop and validate a novel inflammation- and IR-related marker in patients with cancer.
View Article and Find Full Text PDFBackground: Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in patients with cancer.
Methods: This multicenter prospective study included 5,221 patients with cancer, with a mean age of 59.
Background: Overweight or obese cancer patients are more likely to develop a proinflammatory status. The aim of this study was to investigate whether the nutrition-inflammation marker can provide additional prognostic information on top of well-established Eastern Cooperative Oncology Group performance status (ECOG-PS) in overweight or obese patients with cancer.
Methods: A total of 1667 overweight or obese cancer patients were enrolled in this study.
Systemic inflammation with sarcopenia predicts survival in patients with gastric cancer.
J Cancer Res Clin Oncol
March 2023
Objective: The levels of platelet-related inflammation indicators and sarcopenia have been reported to affect the survival of patients with cancer. To evaluate the prognostic influence of platelet count (PLT), platelet lymphocyte ratio (PLR), and systemic immune inflammation index (SII), and SII combined with sarcopenia on the survival of patients with gastric cancer (GC).
Methods: A total of 1133 patients with GC (812 male and 321 female, average age: 59.
Objective: Systemic inflammation and malnutrition are correlated with cancer sarcopenia and have deleterious effects on oncological outcomes. However, the combined effect of inflammation and malnutrition in patients with cancer sarcopenia remains unclear.
Methods: We prospectively collected information on 1,204 patients diagnosed with cancer sarcopenia.
Article Synopsis
- A study was conducted to develop and validate a simplified version of the Patient-Generated Subjective Global Assessment (mPG-SGA) for cancer patients, aiming to reduce the time required to complete the assessment.
- Experts evaluated the existing PG-SGA for its clarity and difficulty, leading to a refined mPG-SGA that accurately categorizes nutritional status and predicts patient survival based on nutrition.
- Results showed that patients categorized by the mPG-SGA had significant differences in median overall survival, highlighting its effectiveness compared to the original PG-SGA and the abridged version.
Background: Systemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The survival outcomes of elderly patients with cancer cachexia (EPCC) with high inflammation and a high risk of mortality are unknown. This study aimed to investigate the impact of high inflammation on the prognosis of EPCC patients with high mortality.
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