Publications by authors named "Cong Ma"

3-Methyl-4-nitrophenol (PNMC) is a prevalent nitrophenolic endocrine disruptor found in pregnant women, with known effects on offspring growth and development. However, its impact on offspring fertility remains unexplored. This study investigates the effects of PNMC exposure during pregnancy on offspring fertility and the underlying mechanisms.

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Document Image Translation (DIT) aims to translate texts on document images from one language to another. It is a multi-modal task involving cooperation of text and layout. Current approaches either handle layout and translation as separate processes, risking accumulative errors, or use vanilla end-to-end encoder-decoder models to capture layout implicitly, often suffering inadequate layout incorporation.

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All-solid-state batteries (ASSBs) represent a transformative advancement in energy storage, distinguished by their superior safety and energy density. However, the sustainable development of ASSBs depends critically on the effective recycling of solid electrolytes and electrode materials from spent batteries, which poses significant challenges. Here, we present a facile and high-value-added carbothermal strategy for recycling spent poly(ethylene oxide) (PEO)-based electrolytes.

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High-speed impact loading has a crucial effect on pore compaction and microscopic crack evolution for shale at different confining pressure (P). In this study, we selected the shales from Jiangxi (JX) and Sichuan Province (SC) in China, and then performed Split Hopkinson pressure bar (SHPB) experiments at P = 0, 5, 15, and 25 MPa. Further, the impacted shales were tested by low temperature nitrogen adsorption (LTNA), mercury intrusion porosimetry (MIP) and environmental scanning electron microscope (ESEM).

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Objective: The prevalence of prediabetes among adults in the U.S. is three times higher than that of diabetes, highlighting a greater disease burden.

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This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023.

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The balance between synaptic excitation and inhibition (E/I) is essential for coordinating motor behavior, yet the differential roles of exocytosis regulators in this balance are less understood. In this study, we investigated the roles of 2 conserved exocytosis regulators, complexin/CPX-1 and CAPS/UNC-31, in excitatory versus inhibitory synapses at Caenorhabditis elegans neuromuscular junctions. cpx-1 null mutants exhibited a marked increase in spontaneous release specifically at excitatory synapses, alongside an unequal reduction in excitatory and inhibitory evoked release.

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Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity. This catalytic reaction can not only be applied to aryl chlorides/bromides, which are challenging to access by other means, but also to benzyl chlorides containing silicon groups. Additionally, the absence of a sacrificial anode lays a foundation for scalability.

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Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.

Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes - CCNB1, CDC25C, HSP90AA1, and PARP1 - that significantly correlate with MM prognosis, with high expression indicating poor outcomes.

Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival.

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Spatially resolved transcriptomics technologies provide high-throughput measurements of gene expression in a tissue slice, but the sparsity of these data complicates analysis of spatial gene expression patterns. We address this issue by deriving a topographic map of a tissue slice-analogous to a map of elevation in a landscape-using a quantity called the isodepth. Contours of constant isodepths enclose domains with distinct cell type composition, while gradients of the isodepth indicate spatial directions of maximum change in expression.

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ConspectusIn recent years, our research group has dedicated significant effort to the field of asymmetric organometallic electrochemical synthesis (AOES), which integrates electrochemistry with asymmetric transition metal catalysis. On one hand, we have rationalized that organometallic compounds can serve as molecular electrocatalysts (mediators) to reduce overpotentials and enhance both the reactivity and selectivity of reactions. On the other hand, the conditions for asymmetric transition metal catalysis can be substantially improved through electrochemistry, enabling precise modulation of the transition metal's oxidation state by controlling electrochemical potentials and regulating the electron transfer rate via current adjustments.

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Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the dual-purpose SNARE complex mediating autophagosome-lysosome fusion in both bulk and selective autophagy. However, the spatiotemporal regulatory mechanisms of this SNARE complex remain unknown.

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Patients suffering from psoriatic arthritis (PsA) often experience depression due to chronic joint pain, which significantly hinders their recovery process. However, the relationship between these two conditions is not well understood. Through a review of existing studies, we revealed that certain neuroendocrine hormones and neurotransmitters are involved in the neuroimmune interactions related to both PsA and depression.

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Large-amount encapsulation and subsequent expressing are common characteristics for many biomedical applications, such as cosmetic creams and medical ointments. Emulsion gels can accomplish that, but often undergo exclusive, complex, multiple synthesis steps, showing extremely laborious and non-universal. The method here is simple via precisely interfacial engineering in homogenizing a nanoparticle aqueous dispersion and a polymer oil solution, gaining interfacial 45° three-phase-contact-angle for the nanoparticle that can bridge across oil emulsions' interfaces and ultimately form interconnected macroscopic networks.

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Biofouling has been one of the major challenges impacting the long-term stable operation of ultrafiltration processes. Irreversible biofouling is considerably more harmful than reversible biofouling. Conductive membrane, as a new technology to effectively mitigate membrane fouling, lack research of controlling irreversible biofouling.

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Climate change has increased the frequency and severity of extreme heat events globally, adversely affecting socio-economic conditions and public health. However, extreme heat has disparate effects on different population groups and the socio-economic determinants of its health effects are not well understood. In this study, we analyzed the spatial patterns of heat-related illness (HRI) visit rates at the zip-code level in Florida and applied statistical methods to examine the relationships between HRIs and environmental and socio-economic variables.

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Molybdenum diphosphide (MoP), a topological semimetal, possesses distinctive properties and applications in catalysis, energy storage, and condensed matter physics. However, synthesizing high-purity MoP is complex and often results in undesired stoichiometric by-products. Additionally, the intrinsic orthorhombic crystal structure makes it difficult to synthesize MoP in a 2D morphology, which is desirable for device and energy applications.

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Antibiotic resistance genes (ARGs) are emerging contaminants of significant concern due to their role in facilitating the spread of antibiotic resistance, especially high-risk ARGs, which are characterized by high human accessibility, gene mobility, pathogenicity, and clinical availability. Studies have shown that cross-domain interactions, such as those between consumer protists (consumers) and bacteria, can influence bacterial diversity, distribution, and function through top-down control. The consumers-bacteria interactions may also affect the occurrence and distribution of ARGs, yet this has been scarcely explored in field investigations.

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Arsenic is a pollutant that can cross the placenta; however, research on the effects of arsenic exposure during pregnancy on the fertility of female offspring is limited. To address this gap, we developed a mouse model to investigate the relationship between arsenic exposure during pregnancy and fertility in female offspring. Our fertility assessment revealed that gestational exposure to 1 mg/kg arsenic or higher (10 mg/kg) resulted in reduction in litter size, ovarian volume, and multistage-follicle number in female offspring.

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Article Synopsis
  • This study presents a method for successfully creating subnanometric bimetallic clusters (SBCs), specifically PtW SBCs, with a consistent size of 0.81 nm supported on N-doped carbon, addressing challenges in achieving effective SBC exposure.
  • The electrostatic interaction between negatively charged polyanions and positively charged metal-organic frameworks facilitates this synthesis, leading to the development of an efficient electrocatalyst for hydrogen evolution reactions.
  • The PtW/NC catalyst demonstrates impressive performance, including a low overpotential of 4 mV and a significantly higher Pt mass activity compared to commercial catalysts, attributed to the synergistic effect between platinum and tungsten.
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Internal alkynes are often contained in bioactive pharmaceuticals and crucial intermediates in material sciences, yet their production methods are often limited and challenging, necessitating the development of more efficient and versatile synthetic routes. Here we report a method of deoxygenative alkynylation of alcohols via flow photochemistry. Formation of N-heterocyclic carbene-alcohol adducts undergoes oxidation by a photocatalyst, generating alkyl radicals.

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Article Synopsis
  • - Vitiligo is a skin disorder characterized by loss of pigmentation, affecting both the appearance and mental well-being of those affected, as it involves a decrease in functioning melanocytes which produce skin color.
  • - Treatment options for vitiligo include glucocorticoids, immunosuppressants, phototherapy, and surgical methods, but recent studies highlight the role of Janus kinase (JAK) hyperactivation and pro-inflammatory cytokines in escalating the condition by harming melanocytes.
  • - New research shows that JAK inhibitors can effectively counteract the negative effects of these signaling pathways, leading to potential repigmentation of the skin, and this review discusses their mechanisms and applications for improving vitiligo treatments.
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The self-assembled monolayer (SAM) technique, known for its customizable molecular segments and active end groups, is widely recognized as a powerful tool for regulating the interfacial properties of high-energy-density lithium metal batteries. However, it remains unclear how the degree of long-range order in SAMs affects the solid electrolyte interphase (SEI). In this study, we precisely controlled the hydrolysis of silanes to construct monolayers with varying degrees of long-range order and investigated their effects on the SEI nanostructure and lithium anode performance.

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Article Synopsis
  • The regenerative ability of peripheral nervous system neurons, specifically dorsal root ganglion (DRG) neurons, is limited, and the effects of mechanical signals on their axon regrowth are not fully understood.
  • This study investigates how varying substrate stiffness influences axon regrowth in cultured DRG neurons from newborn rats, finding that optimal stiffness is essential for this process.
  • It also reveals that the mechanosensitive channel Piezo1 helps detect stiffness and regulates axon regrowth through a specific signaling pathway, with knockdown of Piezo1 in adult neurons leading to better regeneration and quicker recovery after nerve injury, suggesting a new target for therapies.
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To study the spatial interactions among cancer and non-cancer cells, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined 'tumour microregions' as spatially distinct cancer cell clusters separated by stromal components.

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