Imaging diagnosis of cryptogenic multifocal ulcerous stenosing enteritis.

Objective: This study aimed to summarize the intestinal ultrasound (IUS) and computed tomography enterography (CTE) features of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) and compare the performance of IUS and CTE in the evaluation of CMUSE in a single tertiary center.

Methods: Clinically or pathologically confirmed CMUSE patients between December 2009 and April 2023 were recruited. Imaging features of CMUSE patients who underwent both IUS and CTE were summarized retrospectively.

The intracellular domain of TLR2 is capable of high-affinity Zn binding: possible outcomes for the receptor activation.

Toll-like receptors (TLRs) are important players in the innate immune system. Binding of pathogen-related molecules to the extracellular domains of TLRs initiates signalosome assembly, a key event in signal transduction. Despite extensive research on individual receptor domains, the mechanism of signalosome assembly remains unclear.

A UDP-glucuronosyltransferase gene UGT379A1 involved in detoxification of lufenuron in Diaphorina citri.

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae), is a devastating bacterial disease of commercial citrus. Presently, uridine diphosphate (UDP)-glycosyltransferases (UGTs), have been linked to the detoxification of pesticides, were known as phase II enzymes in the detoxification process. However, the role of UGTs in detoxification of lufenuron in Diaphorina citri is unknown.

Development and internal validation of a risk prediction model for dementia in a rural older population in China.

Introduction: We sought to develop a practical tool for predicting dementia risk among rural-dwelling Chinese older adults.

Methods: This cohort study included 2220 rural older adults (age ≥ 65 years) who were dementia-free at baseline (2014) and were followed in 2018. Dementia was diagnosed following the DSM-IV criteria.

Polymorphic relaxor phase and defect dipole polarization co-reinforced capacitor energy storage in temperature-monitorable high-entropy ferroelectrics.

Energy storage high-entropy ceramics are famous for their ultrahigh power density and ultrafast discharge rate. However, achieving a synchronous combination of high energy density and efficiency along with intelligent temperature-monitorable function remains a significant challenge. Here, based on high-entropy strategy and phase field simulation, the polarization response of domains in BiNaTiO-based ceramics is optimized by constructing a concomitant nanostructure of defect dipole polarization and a polymorphic relaxor phase.

Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer.

Purpose: To understand the broader genetic landscape of male breast cancer (MBC), focusing on the utility of genome sequencing (GS) beyond (HGNC: 1100, 1101) variants.

Methods: Twenty-four patients with MBC underwent a multistep genetic analysis. Initial screening targeted variants followed by GS to identify pathogenic/likely pathogenic germline variants through a 3-tiered classification.

Dual-metal heterogeneous electrode enabling efficient co-electrosynthesis of adipic acid and hydrogen.

The electrochemical oxidation of cyclohexanone to produce adipic acid (AA), coupled with hydrogen (H) production, represents a promising strategy. However, the development of low-cost and high-performance electrodes remains a significant challenge. Herein, we present Ni@Cu dual-metal heterogeneous material as a proof of concept, demonstrating its potential for efficient co-electrosynthesis of adipic acid and H.

DPD-YOLO: dense pineapple fruit target detection algorithm in complex environments based on YOLOv8 combined with attention mechanism.

With the development of deep learning technology and the widespread application of drones in the agricultural sector, the use of computer vision technology for target detection of pineapples has gradually been recognized as one of the key methods for estimating pineapple yield. When images of pineapple fields are captured by drones, the fruits are often obscured by the pineapple leaf crowns due to their appearance and planting characteristics. Additionally, the background in pineapple fields is relatively complex, and current mainstream target detection algorithms are known to perform poorly in detecting small targets under occlusion conditions in such complex backgrounds.

Structure-Guided Engineering of a Versatile Urethanase Improves Its Polyurethane Depolymerization Activity.

Polyurethane (PUR), the fifth most prevalent synthetic polymer, substantially contributes to the global plastic waste problem. Biotechnology-based recycling methods have recently emerged as innovative solutions to plastic waste disposal and sparked interest among scientific communities and industrial stakeholders in discovering and designing highly active plastic-degrading enzymes. Here, the ligand-free crystal structure of UMG-SP2, a metagenome-derived urethanase with depolymerization activities, at 2.

DeepPrep: an accelerated, scalable and robust pipeline for neuroimaging preprocessing empowered by deep learning.

Neuroimaging has entered the era of big data. However, the advancement of preprocessing pipelines falls behind the rapid expansion of data volume, causing substantial computational challenges. Here we present DeepPrep, a pipeline empowered by deep learning and a workflow manager.

MicroRNA‑96 promotes the proliferation and migration of breast cancer cells by inhibiting Smad7 expression.

The present study aimed to investigate the effects of microRNA (miR)-96 on the proliferation and migration of breast cancer cells, and indicated that miR-96 may have a promoting role in breast cancer by inhibiting Smad7. Reverse transcription-quantitative (RT-q)PCR was used to detect the expression levels of miR-96 and Smad7 in breast cancer tissues and adjacent tissues. Western blotting and immunohistochemistry were conducted to determine the expression levels of SMAD7 in breast cancer and adjacent tissues.

Industrial-Level Paired Electrosynthesis of Valuable Chemicals over a High-Performance Heterostructural Electrode.

Paired electrosynthetic technology is of significance to realize the co-production of high-added value chemicals. However, exploiting efficient bifunctional electrocatalyst of the concurrent electrocatalysis to achieve the industrial-level performance is still challenging. Herein, an amorphous CoP@MoO heterostructure is rationally designed by in situ electrodeposition strategy, which is acted as excellent bifunctional catalysts for the electrocatalytic nitrite reduction reaction (NORR) and glycerol oxidation reaction (GOR).

Identification and functional characterization of UDP-glycosyltransferase genes involved in cyetpyrafen resistance in Panonychus citri (McGregor).

Background: Cyetpyrafen is a newly developed acaricide. The citrus red mite, Panonychus citri (McGregor), is an important citrus pest that has developed resistance to cyetpyrafen. Uridine diphosphate-glycosyltransferases (UGTs) have been widely reported to be associated with resistance to multiple acaricides.

Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs.

In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigate the lymphatic draining function at the tibial fracture sites using near-infrared indocyanine green lymphatic imaging (NIR-ICG) and discover that lymphatic drainage insufficiency (LDI) starts on day one and persists for up to two weeks following the fracture in male mice.

Estimated pulse wave velocity associated with cognitive phenotypes in a rural older population in China: A cohort study.

Introduction: To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population.

Methods: This population-based study included 1857 dementia-free participants (age ≥60 years) who were examined in 2014 and followed in 2018. ePWV was calculated using age and mean blood pressure (MBP).

A dataset of Uniswap daily transaction indices by network.

Decentralized Finance (DeFi) is reshaping traditional finance by enabling direct transactions without intermediaries, creating a rich source of open financial data. Layer 2 (L2) solutions are emerging to enhance the scalability and efficiency of the DeFi ecosystem, surpassing Layer 1 (L1) systems. However, the impact of L2 solutions is still underexplored, mainly due to the lack of comprehensive transaction data indices for economic analysis.

Icariin improves learning and memory function by enhancing HRD1-mediated ubiquitination of amyloid precursor protein in APP/PS1 mice.

Background: One of the hallmark pathological characteristics of Alzheimer's disease (AD) is amyloid-β (Aβ) accumulated in brain, which is mainly derived from the proteolytic processing of amyloid-β protein precursor (AβPP). The ubiquitin-proteasome system is able to reduce Aβ generation by ubiquitination and degradation of AβPP. Icariin (ICA), a flavonoid isolated from Maxim.

Associations between lifelong cognitive reserve, Alzheimer's disease-related plasma biomarkers, and cognitive function in dementia-free older adults: A population-based study.

Background: Cognitive reserve (CR), typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology.

Objective: To examine the associations of CR with mild cognitive impairment (MCI) and cognitive function while considering Alzheimer's disease (AD)-related plasma biomarkers.

Methods: This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China.

Enhancement of prefrontal functional connectivity under the influence of concurrent physical load during mental tasks.

Backgrounds: Functional near-infrared spectroscopy (fNIRS) is widely used for the evaluation of mental workload (MWL), but it is not yet clear whether it is affected by physical factors during cognitive tasks. Therefore, the combined effects of physical and cognitive loads on hemodynamic features in the prefrontal cortex were evaluated.

Methods: Thirty-three eligible healthy male subjects were asked to perform three types of cognitive tasks (1-back, 2-back and 3-back).

Gene Deficiency of δ Subunit-Containing GABA Receptor in mPFC Lead Learning and Memory Impairment in Mice.

Maintaining GABAergic inhibition within physiological limits in the medial prefrontal cortex (mPFC) is critical for working memory. While synaptic GABAR typically mediate the primary component of mPFC inhibition, the role of extrasynaptic δ-GABAR in working memory remains unclear. To investigate this, we used fiber photometry to examine the effects of δ-GABAR in freely moving mice.

Gender Differences in Acute Type A Aortic Dissection: A Comprehensive Review and Meta-Analysis.

We aimed to undertake a meta-analysis of cohort studies to evaluate gender-based differences for patients with acute type A aortic dissection. A systematic search was performed across PubMed, Embase, and Cochrane Library (2000 to 2023) for studies reporting gender-related discrepancies in clinical presentation, in-hospital management, and/or outcomes. Study effects were assessed using mean difference or risk ratio (RR) as aggregated estimates.

Chromatin accessibility reveals potential prognostic value of the peak set associated with smoking history in patients with lung adenocarcinoma.

Considerable differences in molecular characteristics have been defined between non-smoker and smokers in patients with lung adenocarcinoma (LUAD), yet studies on open chromatin patterns associated with LUAD progression caused by smoking are still lacking. Here, we constructed a novel network based on correlations between each ATAC-seq peak from TCGA data using our previously developed algorithm. Subsequently, principal component analysis was performed on LUAD samples with retained peaks filtered by the correlation network, and pathway analysis was conducted to identify potential pathways involved.

Superior Temperature Sensing and Capacitive Energy-Storage Performance in Pb-Free Ceramics.

The ultrafast charge/discharge rate and high power density (P) endow lead-free dielectric energy storage ceramics (LDESCs) with enormous application potential in electric vehicles. However, their low energy storage density and single energy storage performance (ESP) limit their further development and applicability in rugged environments. Here, through the design of vacancy defects and phase structure regulation, Pb-free (BiNa)TiO-based ceramics with an optimal composition can achieve a large maximum polarization (>44 µC cm) under a moderate electric field (410 kV cm), resulting in an extremely high recoverable energy storage density (≈6.