Clinical significance of cylindromatosis expression in primary hepatocellular carcinoma.

Background And Study Aim: There is currently a lack of sensitive biomarkers for the diagnosis of hepatocellular carcinoma (HCC). Low expression of cylindromatosis (CYLD), a tumor suppressor gene that encodes a deubiquitinase, is associated with the development of HCC. The present study, therefore, aimed to determine the clinical utility of measuring CYLD expression in the early diagnosis of HCC.

Pesticide fate at watershed scale: A new framework integrating multimedia behavior with hydrological processes.

Pesticide pollution has been one serious ecological and environmental issue due to its wide application, high toxicity, and complex environmental behavior. The fugacity model has been widely used to quantify biogeochemical cycles of pesticides due to its clear compartments, simple structure, and easy-accessible data. However, the lack of detailed hydrological processes limits its application for large and heterogeneous watershed.

Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells.

Aim: To observe the role and mechanism of autophagy in retinal pigment epithelial cell (RPE) damaged by high glucose, so as to offer a new idea for the treatment of diabetic retinopathy (DR).

Methods: ARPE-19, a human RPE cell line cultured was divided into the normal control (NC), autophagy inhibitor 3-methyladenine (3-MA), high-glucose (HG), and HG+3-MA groups. Cell viability was detected by CCK-8 assay and the apoptosis rate was measured by flow cytometry.

Evaluating national ecological risk of agricultural pesticides from 2004 to 2017 in China.

In recent years, excessive application and loss of pesticides have caused great risks to the aquatic systems, but the spatio-temporal variability in the ecological risk that agricultural pesticides pose to aquatic systems has not been explored at the national scale. In this study, an integrated assessment framework was proposed for the potential ecological risk of surface water caused by agricultural pesticide loss. The spatio-temporal variability in the potential ecological risk caused by agricultural pesticide runoff was evaluated.

National assessment of spatiotemporal loss in agricultural pesticides and related potential exposure risks to water quality in China.

Pesticide loss during agricultural development has a serious effect on related water quality, and the critical concern is quantifying the potential exposure risks that pesticide loss pose to water quality at the national scale. In this study, an integrated assessment framework is proposed to scale emission factors from 232 monitoring plots to the national scale, while also considering the physicochemical properties of pesticides in dissolved or adsorbed forms. Based on the results of this study, the total pesticide emissions increased by 29.

Tungstate removal from aqueous solution by nanocrystalline iowaite: An iron-bearing layered double hydroxide.

Tungstate enrichment in aquatic systems may cause negative environmental and health effects. This study addresses tungstate removal from aqueous solution by nanocrystalline iowaite, an iron-bearing layered double hydroxide, which has not been used for treatment of tungstate-rich waters so far. Tungstate sorption experiments were conducted with various contact times, temperatures, initial tungstate concentrations (0.