Publications by authors named "Conejo-Mir-Sanchez J"
Article Synopsis
- - Biological therapy, specifically brodalumab, shows promise in treating hidradenitis suppurativa (HS) by targeting the IL-17 receptor, which may play a role in the disorder's immune dysregulation.
- - A study involving 16 adults with moderate to severe HS found that 50% achieved an improvement in symptoms and experienced a significant decrease in disease severity after 16 weeks of brodalumab treatment.
- - The treatment was generally safe, with some patients experiencing mild adverse effects, suggesting that brodalumab is a viable option for those who did not respond to previous biologics like adalimumab.
Article Synopsis
- Lipoid proteinosis (LP) is a rare genetic skin disorder caused by ECM1 gene mutations, leading to abnormal material accumulation in skin and organs.
- The case report focuses on a 48-year-old man with LP who improved significantly after treatment with oral acitretin, while a systematic review was conducted to gather and evaluate related studies on LP management.
- The review included 25 studies and analyzed data from 44 patients, suggesting that low-dose acitretin may be a promising treatment option with fewer side effects, but highlights the need for further research to develop better treatment guidelines.
Article Synopsis
- - Oculocutaneous albinism (OCA) is a genetic disorder affecting melanin production, studied in pediatric patients through dermatological and ophthalmological exams, including advanced imaging techniques like OCT.
- - The study found that individuals with a single pathogenic mutation showed milder symptoms, while more severe cases were linked to a greater number of genetic mutations and polymorphisms.
- - A common observation across all OCA subgroups was paler dermoscopic patterns, particularly varied vascular patterns, which indicated more severe presentations of the disease.
Thermography for the follow-up of skin and soft tissue infections.
Enferm Infecc Microbiol Clin (Engl Ed)
June 2023
Background: Ultraviolet radiation is the main environmental risk factor responsible for the development of skin cancer. Other occupational, socioeconomic, and environmental factors appear to be related to the risk of skin cancer. Furthermore, the factors appear to differ for melanoma and non-melanoma skin cancer (NMSC).
View Article and Find Full Text PDFBasal cell carcinoma (BCC) is the most common skin cancer, and its incidence is rising. Millions of benign biopsies are performed annually for BCC diagnosis, increasing morbidity, and healthcare costs. Non-invasive in vivo technologies such as multiphoton microscopy (MPM) can aid in diagnosing BCC, reducing the need for biopsies.
View Article and Find Full Text PDFEfficacy and safety of biological therapy in patients with psoriasis and recent neoplasia: experience in real single-center clinical practice.
Arch Dermatol Res
May 2023
Ex vivo confocal microscopy (EVCM) generates digitally colored purple-pink images similar to H&E without time-consuming tissue processing. It can be used during Mohs surgery for rapid detection of basal cell carcinoma (BCC); however, reading EVCM images requires specialized training. An automated approach using a deep learning algorithm for BCC detection in EVCM images can aid in diagnosis.
View Article and Find Full Text PDFBackground: Vascular malformations are a complex pathology with few treatment options. In previously published studies, oral sirolimus (rapamycin) has shown promising results in the treatment of low-flow vascular malformations, but its usefulness in high-flow vascular malformations is controversial.
Aim: To evaluate the efficacy and safety of sirolimus for the treatment of high-flow vascular malformations in real-life practice.
Ex Vivo Fluorescence Confocal Microscopy on a 3-Color Scale: A New Imaging Technique.
Actas Dermosifiliogr (Engl Ed)
October 2020
Article Synopsis
- Desmoplastic giant congenital melanocytic nevus (DGCN) is a rare type of birthmark that can become hard and lose color over time, sometimes leading to hair loss or the nevus disappearing.
- A case was observed in a 6-month-old girl with this type of nevus covering the entire back of her right thigh, which showed significant changes after nine months.
- Dermoscopy revealed a unique pattern in the affected area that resembled a "sky full of stars," specifically concentrated around hair follicles, highlighting the distinctive appearance of DGCN.
Introduction: Urticarial vasculitis is a subtype of vasculitis characterized clinically by urticarial lesions and histologically by necrotizing vasculitis.
Objective: To study the clinical and histologic features of urticarial vasculitis in patients seen in the dermatology department of Hospital Universitario Virgen de Rocío in Seville, Spain, and to examine the association between hypocomplementemia and systemic disease.
Material And Methods: We performed a chart review of histologically confirmed cases of urticarial vasculitis in the database of our department covering a period of 10 years.