Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.

is the most common cause of fungal meningitis and the top-ranked W.H.O.

A dataset of over one thousand computed tomography scans of battery cells.

Battery technology is increasingly important for global electrification efforts. However, batteries are highly sensitive to small manufacturing variations that can induce reliability or safety issues. An important technology for battery quality control is computed tomography (CT) scanning, which is widely used for non-destructive 3D inspection across a variety of clinical and industrial applications.

Public experiences and perspectives of primary care in Canada: results from a cross-sectional survey.

Background: Through medicare, residents in Canada are entitled to medically necessary physician services without paying out of pocket, but still many people struggle to access primary care. We conducted a survey to explore people's experience with and priorities for primary care.

Methods: We conducted an online, bilingual survey of adults in Canada in fall 2022.

Communication and coordination of care for people living with HIV: a qualitative study of the patient perspective.

Background: There is growing consensus that primary health care (PHC) providers have an important role in providing holistic, preventative care for people living with human immunodeficiency virus (PLHIV). In regional Australia, HIV care is primarily delivered through specialist services, thus adequate coordination and communication between specialist and PHC professionals is crucial. This study aimed to explore patient experiences of the coordination of care and health care professional communication for PLHIV in regional Australia.

Does it work? Resident selection and implicit bias training for postgraduate program directors.

One element to address health disparities and historical injustices of systemically excluded groups is to examine selection processes. Implicit association testing for selection committees is suggested as one intervention to address bias in selection and is used for Undergraduate Medical Education at the University of Manitoba. Our study demonstrated that implicit bias training for PDs in isolation has minimal impact on addressing bias within resident selection.

Isometric Hamming embeddings of weighted graphs.

A mapping from the vertex set of one graph to another graph is an if the shortest path distance between any two vertices in equals the distance between their images in . Here, we consider isometric embeddings of a weighted graph into unweighted Hamming graphs, called Hamming embeddings, when satisfies the property that every edge is a shortest path between its endpoints. Using a Cartesian product decomposition of called its , we show that every Hamming embedding of may be partitioned into a , whose parts provide Hamming embeddings for each factor of the canonical isometric representation of .

AlignOT: An Optimal Transport Based Algorithm for Fast 3D Alignment With Applications to Cryogenic Electron Microscopy Density Maps.

Aligning electron density maps from Cryogenic electron microscopy (cryo-EM) is a first key step for studying multiple conformations of a biomolecule. As this step remains costly and challenging, with standard alignment tools being potentially stuck in local minima, we propose here a new procedure, called AlignOT, which relies on the use of computational optimal transport (OT) to align EM maps in 3D space. By embedding a fast estimation of OT maps within a stochastic gradient descent algorithm, our method searches for a rotation that minimizes the Wasserstein distance between two maps, represented as point clouds.

Determinants of access to general practice in a shared care model for people living with HIV: a qualitive study of patients' perspectives in an Australian rural community.

Background: Improved management of human immunodeficiency virus (HIV) has resulted in improved life expectancy for people living with HIV and an ageing population with a significant comorbidity burden. Shared care models, involving the co-ordinated liaison between general practitioners and specialist physicians, have been advocated for in Australia to provide comprehensive care. People living with HIV in rural areas have reduced access to general practice and therefore shared care.

Factorization and pseudofactorization of weighted graphs.

For unweighted graphs, finding isometric embeddings of a graph is closely related to decompositions of into Cartesian products of smaller graphs. When is isomorphic to a Cartesian graph product, we call the factors of this product a factorization of . When is isomorphic to an isometric subgraph of a Cartesian graph product, we call those factors a pseudofactorization of .

Rapid cell type-specific nascent proteome labeling in .

Controlled protein synthesis is required to regulate gene expression and is often carried out in a cell type-specific manner. Protein synthesis is commonly measured by labeling the nascent proteome with amino acid analogs or isotope-containing amino acids. These methods have been difficult to implement in vivo as they require lengthy amino acid replacement procedures.

Predicting DNA kinetics with a truncated continuous-time Markov chain method.

Predicting the kinetics of reactions involving nucleic acid strands is a fundamental task in biology and biotechnology. Reaction kinetics can be modeled as an elementary step continuous-time Markov chain, where states correspond to secondary structures and transitions correspond to base pair formation and breakage. Since the number of states in the Markov chain could be large, rates are determined by estimating the mean first passage time from sampled trajectories.

Accuracy of Caudocranial Canine Femoral Radiographs Compared to Computed Tomography Multiplanar Reconstructions for Measurement of Anatomic Lateral Distal Femoral Angle.

Objective:  This study aimed to compare the accuracy of sternal recumbency caudocranially obtained radiographs of canine femora to computed tomographic (CT) frontal plane reconstructions of the same femora for assessing anatomic distal lateral femoral angles (aLDFA).

Study Design:  Multicentre, retrospective study utilizing 81 matched radiographic and CT studies of clinical patients undergoing assessment for various issues were reviewed. Anatomic lateral distal femoral angles were measured, and accuracy assessed with descriptive statistics and Bland-Altman plot analysis, with CT considered the reference standard.

Home-based primary care in Canada: Five innovative urban practices.

Problem Addressed: While the home-based primary care model offers potential patient and system-level benefits, implementation of interprofessional home-based primary care teams has not been widespread. When caring for homebound patients, family physicians are often not included as regular contributors or participants in the team that coordinates and plans much of the care for these patients.

Objective Of Program: To describe a selection of home-based primary care practices and to identify barriers to and facilitators of the creation and sustainability of these models within the publicly funded health care system.

Co-activation of GPCRs facilitate GIRK-dependent current.

The activity of dopamine neurons is dependent on both intrinsic properties and afferent projections. One potent form of inhibition is mediated by the activation of two inhibitory G protein-coupled receptors, D2 and GABA receptors. Each of these receptors activates G protein-coupled inwardly rectifying potassium (GIRK) channels.

Comparative study of a single lead ECG in a wearable device.

Background: Technological advances have led to electrocardiograph (ECG) functionality becoming increasingly accessible in wearable health devices, which has the potential to vastly expand the clinician's ability to monitor, diagnose, and manage cardiac health conditions. However, achieving the high signal quality necessary to make an accurate and confident diagnosis is inherently challenging on consumer device-acquired ECGs. Effective signal conditioning is crucial to make ECG data from wearable devices clinically actionable.

Education Standards for Pharmacists Providing Comprehensive Medication Management in Outpatient Nephrology Settings.

Chronic kidney disease is a public health problem that has generated renewed interest due to poor patient outcomes and high cost. The Advancing American Kidney Health initiative aimed to transform kidney care with goals of decreasing the incidence of kidney failure and increasing the number of patients receiving home dialysis or a kidney transplant. New value-based models of kidney care that specify inclusion of pharmacists as part of the kidney care team were developed to help achieve these goals.

Genotypic variation and covariation in wheat seedling seminal root architecture and grain yield under field conditions.

Greater embryo size in a large and carefully phenotyped mapping population was genetically associated with a greater number of longer seminal roots to increase grain yield in droughted field environments. Breeding modification of root architecture is challenging in field environments owing to genetic and phenotypic complexity, and poor repeatability with root sampling. Seeds from a large mapping population varying in embryo size were harvested from a common glasshouse and standardised to a common size before assessing in rolled germination paper at 12 and 20 °C for seedling growth.

A universal, high-performance ECG signal processing engine to reduce clinical burden.

Background: Electrocardiogram (ECG) signal conditioning is a vital step in the ECG signal processing chain that ensures effective noise removal and accurate feature extraction.

Objective: This study evaluates the performance of the FDA 510 (k) cleared HeartKey Signal Conditioning and QRS peak detection algorithms on a range of annotated public and proprietary ECG databases (HeartKey is a UK Registered Trademark of B-Secur Ltd).

Methods: Seven hundred fifty-one raw ECG files from a broad range of use cases were individually passed through the HeartKey signal processing engine.

Notes from an Organ Recipient: Once is Enough.

In this paper, the author describes her personal experiences with liver disease and the challenges both before and after receiving an organ transplant. She describes how organs are currently allocated and offers her perspective on what fairness entails in situations where organs fail and patients need multiple organs.

Wheat yield potential can be maximized by increasing red to far-red light conditions at critical developmental stages.

Sensing of neighbours via the Red to Far-Red light ratio (R:FR) may exert a cap to yield potential in wheat. The effects of an increased R:FR inside the canopy were studied in dense wheat mini canopies grown in controlled environments by lowering FR. To distinguish between effects exerted by light sensing and assimilate supply, the treatments were complemented with elevated CO , applied between different developmental timepoints to specifically impact tillering, spike growth, floret fertility and grain filling, in different combinations.

Multi-donor × elite-based populations reveal QTL for low-lodging wheat.

Low-lodging high-yielding wheat germplasm and SNP-tagged novel alleles for lodging were identified in a process that involved selecting donors through functional phenotyping for underlying traits with a designed phenotypic screen, and a crossing strategy involving multiple-donor × elite populations. Lodging is a barrier to achieving high yield in wheat. As part of a study investigating the potential to breed low-lodging high-yielding wheat, populations were developed crossing four low-lodging high-yielding donors selected based on lodging related traits, with three cultivars.