Publications by authors named "Concha Amador Prous"
Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors.
Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs).
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial.
J Antimicrob Chemother
July 2023
Article Synopsis
- Fosfomycin trometamol is being explored as a potential step-down therapy for patients with bacteraemic urinary tract infections caused by multidrug-resistant E. coli (MDR-Ec), though data is limited.
- In the FOREST trial, patients who transitioned from IV treatments to either oral fosfomycin or other oral medications showed similar clinical and microbiological cure rates, with fosfomycin achieving 78.7% success compared to 80.9% for other drugs.
- However, fosfomycin had a significantly higher relapse rate (15% vs. 4.3%), indicating that while it is a viable option, its effectiveness needs further evaluation due to this concern.
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial.
JAMA Netw Open
January 2022
Importance: The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these infections is critical, for which some neglected drugs may be an option.
Objective: To determine whether fosfomycin is noninferior to ceftriaxone or meropenem in the targeted treatment of bacteremic urinary tract infections (bUTIs) due to MDR E coli.
[Clinical manifestations of HIV infection in distinct geographical areas].
Enferm Infecc Microbiol Clin
May 2008
The clinical manifestations of HIV infection vary widely in distinct geographical areas. While HIV-related disease has been well characterized in western countries, relatively few publications have described the clinical manifestations of these diseases in tropical areas, where the vast majority of HIV-infected people are concentrated. In addition, HIV infection may alter the natural history of tropical diseases in several ways and tropical diseases influence the course of HIV infection.
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