Publications by authors named "Concepcion Vilallonga"
Background: The aim of this study was to assess the short-term and long-term consequences of stopping antiretroviral therapy (ART) in patients with preserved immune function.
Methods: This was a randomized 144-week follow-up CD4⁺ T-cell-count-guided treatment-interruption trial. HIV-1-infected adults with plasma HIV-1 RNA<50 copies/ml, CD4⁺ T-cell count >500 cells/μl and nadir CD4⁺ T-cell count >100 cells/μl were randomized to continuous treatment (CT) or treatment interruption (TI) until CD4⁺ T-cell count decreased to <350 cells/μl.
Article Synopsis
- Structured antiretroviral therapy interruption (TI) is often necessary but can lead to negative outcomes; this study investigates strategies to reduce resistance to treatment during TI.
- 106 HIV-1-infected patients on stable treatment were divided into two groups: one continued therapy, while the other followed a staggered interruption approach, stopping certain drugs at different times.
- Results indicated that while staggered interruptions did not completely prevent resistance mutations, they did not always cause virological failure upon resuming therapy, suggesting that ongoing monitoring of plasma RNA may be more indicative of treatment risks than initial testing.