Comparison between ADVIA Chemistry systems Enzymatic Creatinine_2 method and ADVIA Chemistry systems Creatinine method (kinetic Jaffe method) for determining creatinine.

Objective: The aim of this study was two-fold: Firstly, to compare the serum creatinine concentration measured by enzymatic method and uncompensated kinetic Jaffe method, and secondly, to compare the effects of certain interfering substances such as glucose, bilirubin, proteins, triglycerides and hemoglobin on creatinine measurement.

Methods: The determination of serum creatinine concentrations by enzymatic method and uncompensated kinetic Jaffe method was performed on ADVIA® 2400 analyzer. The interfering substances were tested by adding solutions of interference to serum pool with low (62 μmol/L), medium (221 μmol/L) and elevated (486 μmol/L) creatinine concentration.

Assessment of ADVIA Centaur analyzer for the measurement of 25-OH vitamin D.

Background: The aim of the present study was to evaluate some analytical performances of the ADVIA Centaur analyzer for the quantitative measurement of 25-OH Vitamin D [25(OH)D] in serum.

Methods: Serum concentrations of 25(OH)D were determined by a new automated chemiluminescence immunoassay method introduced by Siemens and adapted to an ADVIA Centaur analyzer, and compared with HPLC and a commercial chemiluminescence immunoassay (Liaison DiaSorin).

Results: The assay displayed a low intra-day (CV < 7.