Lithium for Leigh syndrome – damage, benefit, or both?

With interest we read the article by Basterreche et al. about a 23yo female with Leigh syndrome diagnosed at age 4y and manifesting with severe psychomotor impairment, severe self-harm, hetero-aggressions, bilateral hypodensities of the basal ganglia, and cerebellar atrophy.

Midline cutaneous lumbosacral lesions: not always a sign of occult spinal dysraphism.

Objective: The authors report two unusual cases of extraspinal midline lumbosacral lesions that resembled the usual skin markers of occult spina bifida.

Patients And Methods: The pathological diagnosis of the masses was plexiform neurofibroma and mastocytoma, respectively.

Results: Some lesions, as those we are reporting, although occurring at the lumbosacral midline, do not necessarily belong to occult spinal dysraphism, as was initially suspected.