Publications by authors named "Concepcion Hernandez-Chinea"
Article Synopsis
- The study examines how increasing calcium ions in red blood cells affects the process of erythrophagocytosis, which is when macrophages consume these red cells, focusing on the factors that contribute to this process.
- Results indicate that higher levels of internal calcium lead to increased phagocytosis rates, especially when autologous serum is present, enhancing the process by almost double.
- Key mechanisms affecting phagocytosis include binding of IgG antibodies and the activity of the Gárdos channel, with inhibitors of this channel completely blocking the serum's effect on erythrophagocytosis.
Early reports have demonstrated the occurrence of glyoxylate cycle enzymes in several Leishmania species. However, these results have been underestimated because genes for the two key enzymes of the cycle, isocitrate lyase (ICL) and malate synthase (MS), are not annotated in Leishmania genomes. We have re-examined this issue in promastigotes of Leishmania amazonensis.
View Article and Find Full Text PDFNew synthetic compounds based on tetrahydroindenoquinoline structure were evaluated for their in vitro antileishmanial activities. The seven compounds assayed have antiproliferative activities against promastigotes of Leishmania mexicana. Compound 1 and 3 were the most active (IC50 1.
View Article and Find Full Text PDFWith the purpose of studying the antigenic role that factors excreted by Leishmania amastigotes might have during murine infection, immunoblots were carried out with sera from C57BL/6 and BALB/c mice infected with two strains of Leishmania (L.) amazonensis, NR and IFLA/BR. Both strains differ widely in virulence in BALB/c mice.
View Article and Find Full Text PDF