Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.

Background: The phase III PRIMA/ENGOT-OV26/GOG-3012 trial met its primary endpoint. Niraparib first-line maintenance significantly prolonged progression-free survival (PFS) among patients with newly diagnosed advanced ovarian cancer that responded to first-line platinum-based chemotherapy, regardless of homologous recombination deficiency (HRD) status. Final overall survival (OS) results are reported.

Niraparib, Dostarlimab, and Bevacizumab as Combination Therapy in Pretreated, Advanced Platinum-Resistant Ovarian Cancer: Findings From Cohort A of the OPAL Phase II Trial.

Purpose: To report the results of OPAL (ClinicalTrials.gov identifier: NCT03574779) cohort A, a single-arm substudy of niraparib plus dostarlimab and bevacizumab for the treatment of advanced, platinum-resistant ovarian cancer (PROC).

Methods: Participants with PROC who received 1-2 previous lines of therapy were treated with niraparib (200 or 300 mg once daily), dostarlimab (500 mg once every 3 weeks for four 21-day cycles, followed by 1,000 mg once every 6 weeks), and bevacizumab (15 mg/kg once every 3 weeks).

Health-related quality of life in patients with newly diagnosed advanced ovarian cancer treated with niraparib vs placebo: Results from the phase 3 randomized PRIMA/ENGOT-OV26/GOG-3012 trial.

Objective: To assess patient-reported health-related quality of life (HRQoL) in patients with ovarian cancer (OC) who received niraparib as first-line maintenance therapy.

Methods: PRIMA/ENGOT-OV26/GOG-3012 (NCT02655016) enrolled patients with newly diagnosed advanced OC who responded to first-line platinum-based chemotherapy. Patients were randomized (2:1) to niraparib or placebo once daily in 28-day cycles until disease progression, intolerable toxicity, or death.

Deeply Virtual Compton Scattering Cross Section at High Bjorken x_{B}.

We report high-precision measurements of the deeply virtual Compton scattering (DVCS) cross section at high values of the Bjorken variable x_{B}. DVCS is sensitive to the generalized parton distributions of the nucleon, which provide a three-dimensional description of its internal constituents. Using the exact analytic expression of the DVCS cross section for all possible polarization states of the initial and final electron and nucleon, and final state photon, we present the first experimental extraction of all four helicity-conserving Compton form factors (CFFs) of the nucleon as a function of x_{B}, while systematically including helicity flip amplitudes.

Form Factors and Two-Photon Exchange in High-Energy Elastic Electron-Proton Scattering.

We present new precision measurements of the elastic electron-proton scattering cross section for momentum transfer (Q^{2}) up to 15.75  (GeV/c)^{2}. Combined with existing data, these provide an improved extraction of the proton magnetic form factor at high Q^{2} and double the range over which a longitudinal or transverse separation of the cross section can be performed.

Improved Λp Elastic Scattering Cross Sections between 0.9 and 2.0 GeV/c as a Main Ingredient of the Neutron Star Equation of State.

Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state. Yet, compared to other elastic scattering processes, there is very little data on Λ-N scattering.

Systematic review of postoperative rehabilitation interventions after cranial cruciate ligament surgery in dogs.

Objective: To critically evaluate the evidence for rehabilitation interventions following surgery for cranial cruciate ligament disease (CCLD) in dogs.

Study Design: Systematic review.

Methods: Google Scholar and Pubmed databases were searched for studies evaluating postoperative CCLD rehabilitation interventions from 1990 until March 2020 per the international Prospective Register of Systematic Reviews (PROSPERO).

En bloc transurethral resection of bladder tumors: A review of current techniques.

Introduction: Growing interest surrounds the concept of en bloc transurethral resection of bladder tumors (ERBT). Theoretical advantages include improved adherence to oncological principles and potential yield of superior pathological specimens. Multiple ERBT methods exist.

Angewandte Chemie Continues To Evolve into 2022.

In 2021, among other changes, Angewandte Chemie established a new governance structure with ten Advisory Editors and a redefined International Advisory Board (IAB) and introduced new article types. The journal will continue to evolve in 2022 and beyond, with five new IAB members and the move from the use of page numbers to eLocators as the first changes of the new year.

Deep Exclusive Electroproduction of π^{0} at High Q^{2} in the Quark Valence Regime.

We report measurements of the exclusive neutral pion electroproduction cross section off protons at large values of x_{B} (0.36, 0.48, and 0.

Angewandte Chemie's Redefined International Advisory Board: Strengthening Connections between the Journal and Its Community.

Over the past months, the Angewandte Chemie Council and the Executive Committee have carefully reflected on the role of the International Advisory Board (IAB) as we continue to transform Angewandte Chemie into a more inclusive home for excellent science. With the announcement of our redefined IAB in this Editorial, the new governance structure of Angewandte Chemie is completed.

Editorial: Introducing… Advisory Editors and New Author Profiles at Angewandte Chemie.

One year ago, Angewandte Chemie pledged to become a more inclusive and diverse journal. We have made significant progress, but our work is not done. Starting today with the inaugural ten Advisory Editors of the journal and our new Author Profiles "Introducing…", and continuing over the next several months, we are pleased to share our achievements so far and our plans for the future.

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections.

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading to aggravated lung injury with potentially fatal consequences. This hyperactivation is triggered in the lungs through a conserved, direct interaction between MASP-2 and coronavirus nucleocapsid (N) proteins.

Phallus Preservation in Penile Cancer Surgery: Patient-reported Aesthetic & Functional Outcomes.

Objective: To assess patient-reported outcomes of oncoplastic penile reconstruction using standardized questionnaires. Whilst organ-preserving penile cancer surgery has evolved, aiming to preserve genital function, reduce psychological morbidity of radical penectomy, and maximise patient quality of life, few studies have evaluated patients' final perceptions.

Methods: Following ethical approval, patients post partial/radical glansectomy with reconstruction 2016-2019, under a single surgeon, were identified.

Chemistry-An Editorial Journey.

The silver anniversary of Chemistry-A European Journal is a great reason to celebrate and a good opportunity for reflection. This Editorial looks back at the history of the journal through the eyes of the Editorials written by a variety of the key players and stakeholders.

Angewandte Chemie-The Home of Excellent Chemistry.

Opening its doors to even more excellent chemistry, Angewandte Chemie's decision to add Research Articles has further expanded the choices available to authors. The flagship journal of the German Chemical Society now offers a home for all different forms of excellent chemistry.

Strong Partnerships and European Collaboration.

Chemistry-The Essential Element is the motto of the Science Forum Chemistry (Wissenschaftsforum Chemie) taking place in Aachen, Germany. This is fitting both given that this year has been designated the International Year of the Periodic Table of Chemical Elements and that an essential element of science is cooperation and collaboration. This year's conference is cohosted by the German Chemical Society (GDCh), the Dutch Chemical Society (KNCV), and the Belgian Chemical Society (KVCV).

Chemistry for All: Advocating Gender Equality.

International Women's Day is celebrated every year on March 8, and this special issue of Angewandte Chemie focussing on Women in Chemistry coincides with International Women's Day 2019. The breadth and quality of content is testament to the excellent research being done in groups being successfully run by female researchers.