Mutation HOXB13 c.853delT in Martinican prostate cancer patients.

Background: In Martinique, prostate cancer (Pca) incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. Despite the demonstration of a strong familial component, identification of the genetic basis for hereditary Pca is challenging. The HOXB13 germline variant G84E (rs138213197) was described in men of European descent with Pca risk.

[The endocrine pancreas in Varanus niloticus: ultrastructural and cytochemical electron microscopic study and X-ray microdiffraction].

Electron microscopy has confirmed that there are B and A1 insular cells in the Varanidae; nevertheless, the majority of cells are A2. It is the transformation of canalicular and acinar cells that is responsible for insular regeneration. Mixed cell type can be found very frequently.