Dosimetric scorecards express precise clinical intent: alternate hippocampal-sparing whole-brain RapidPlan models favoring target coverage and homogeneity at 30 and 20 Gy.

Introduction: This study develops two new multi-institutional hippocampal-sparing whole-brain RapidPlan™ models (HLS-EC-WB and HMS-EC-WB) inspired by CCTG-CE.7 featuring enhanced target coverage with varying hippocampal sparing (limited and moderate).

Methods: New dosimetric scorecards were created to quantify the models' clinical intent.

Effect of Biofumigation on Population Densities of spp. and spp. and Potato Yield in Eastern Canada.

Biofumigation has been proposed as an alternative to soil fumigation to manage soil-borne diseases including potato early dying disease complex (PED). This study examined the potential of using brown mustard () biofumigation to manage PED under rain-fed potato production in New Brunswick, Canada in two trials between 2017 and 2020 in comparison with chloropicrin fumigation and a conventional barley rotation. Biofumigation increased yield in one trial, but not in a second trial where the potato crop experienced severe drought, whereas chloropicrin fumigation increased yield in both trials.

Dataset on soil carbon dioxide fluxes from an incubation with tropical peat from three different land-uses in Jambi Sumatra Indonesia.

Conversion of tropical peat swamp forests to increase and agricultural production has generated substantial peat carbon loss in the Asia-Pacific region. Different land-uses and management practices oxidize the tropical peat at diverse rates due mainly to different water table levels. In recent years, several studies have measured soil carbon dioxide emissions in-situ; however, only few studies have evaluated the effect of moisture on carbon dioxide fluxes in incubation experiments.

Effects of the toxic dinoflagellate Alexandrium catenella on the behaviour and physiology of the blue mussel Mytilus edulis.

The effects of harmful algae on bivalve physiology are complex and involve both physiological and behavioural responses. Studying those responses is essential to better describe and predict their impact on shellfish aquaculture and health risk for humans. In this study we recorded for two months the physiological response of the blue mussel Mytilus edulis from Eastern Canada to a one-week exposure to a paralytic shellfish poisoning producing dinoflagellate strain of Alexandrium catenella, isolated from the St Lawrence estuary, Canada.

Improving Soil Quality and Potato Productivity with Manure and High-Residue Cover Crops in Eastern Canada.

Under intensive low residue agricultural systems, such as those involving potato ( L.)-based systems, stagnant crop yields and declining soil health and environmental quality are common issues. This study evaluated the effects of pen-pack cow () manure application (20 Mg·ha) and cover crops on nitrate dynamics and soil N supply capacity, subsequent potato yield, selected soil properties, and soil-borne disease.

Siltation negatively affects settlement and gaping behaviour in eastern oysters.

While high levels of siltation are known to be deleterious to eastern oysters (Crassostrea virginica), the collective effect of suspended and bedded sediment is understudied from the perspective of oyster farming and bed restoration. In this study, we used laboratory experiments to explore spat settlement rates on a wild bed proxy substrate (i.e.

The IUHPE Health Promotion Accreditation System - developing and maintaining a competent health promotion workforce.

This commentary reports on the development and implementation of the competency-based IUHPE Health Promotion Accreditation System in the context of workforce capacity as a key activity of the International Union for Health Promotion and Education (IUHPE). The process of developing the System is described, including how it built on, and added to, international research and experience in competency-based approaches to health promotion. An overview of how the System works, its current status and future plans, is presented.

Sensitivity to oil dispersants: Effects on the valve movements of the blue mussel Mytilus edulis and the giant scallop Placopecten magellanicus, in sub-arctic conditions.

In response to accidental oil spills at sea, chemical oil dispersants are utilized to limit negative impacts on nearby littoral zones. However, current evidence suggests that such dispersants may be toxic to aquatic organisms. Blue mussels (Mytilus edulis) and giant scallops (Placopecten magellanicus) were exposed to different environmentally relevant concentrations of oil dispersant and their behavioural responses were closely monitored using high frequency (10Hz) valvometry.

Tubulosquamous Polyp of the Vagina: Misplaced Skene's Glands Analogous to the Male Prostate.

Tubulosquamous polyp (TSP) of the vagina is a rare and benign lesion, best considered along the spectrum of lesions derived from Skene's glands, the female counterpart of male prostatic glands. It is likely underdiagnosed and represents a challenging diagnosis if one is unfamiliar with this entity. We present an illustrative case of TSP occurring as an upper vaginal wall nodule of a 75-year-old woman, with characteristic morphology and broad immunophenotype.

The Mediterranean mussel : responses to climate change scenarios as a function of the original habitat.

The impact of simulated seawater acidification and warming conditions on specimens of the mussel locally adapted to very distinct, widely separated sites in the Mediterranean Sea (Tunisia) and Atlantic Sea (Galicia, NW Spain) was evaluated in relation to key behavioural and eco-physiological parameters. Over the 2-month exposure to the experimental conditions, mussels were fed optimally to ensure that there are no synergistic interactions between climate change drivers and energetic status of the individuals. In general, regardless of origin (Atlantic or Mediterranean), the mussels were rather resilient to acidification for most of the parameters considered and they were able to grow in strongly acidified seawater through an increased feeding activity.

Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis.

Objective: The Maternal Mental Health in Canada, 2018/2019, survey reported that 18% of 7,085 mothers who recently gave birth reported "feelings consistent with postpartum depression" based on scores ≥7 on a 5-item version of the Edinburgh Postpartum Depression Scale (EPDS-5). The EPDS-5 was designed as a screening questionnaire, not to classify disorders or estimate prevalence; the extent to which EPDS-5 results reflect depression prevalence is unknown. We investigated EPDS-5 ≥7 performance relative to major depression prevalence based on a validated diagnostic interview, the Structured Clinical Interview for DSM (SCID).

Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis.

Objectives: Estimates of depression prevalence in pregnancy and postpartum are based on the Edinburgh Postnatal Depression Scale (EPDS) more than on any other method. We aimed to determine if any EPDS cutoff can accurately and consistently estimate depression prevalence in individual studies.

Methods: We analyzed datasets that compared EPDS scores to Structured Clinical Interview for DSM (SCID) major depression status.

Behavioural responses to predators in Mediterranean mussels (Mytilus galloprovincialis) are unaffected by elevated pCO.

Ocean acidification is expected to affect marine organisms in the near future. Furthermore, abrupt short-term fluctuations in seawater pCO characteristic of near-shore coastal regions and high-density aquaculture sites currently have the potential to influence organismal and community functioning by altering animal behaviour. While anti-predator responses in fishes exposed to elevated pCO are well documented, such responses in benthic marine invertebrates are poorly studied.

Modelling bivalve culture - Eutrophication interactions in shallow coastal ecosystems.

Assessing the carrying capacity of ecosystems is crucial to the selection of suitable and sustainable locations for aquaculture farms. In Malpeque Bay (PEI, Canada), the potential expansion of mussel farms has driven a series of numerical modelling studies. We coupled sub-models for sea lettuce, wild and cultured oysters and wild softshell clams to an existing ecosystem model to better understand nutrient dynamics and the carrying capacity of Malpeque Bay.

Drainage increases CO and N O emissions from tropical peat soils.

Tropical peatlands are vital ecosystems that play an important role in global carbon storage and cycles. Current estimates of greenhouse gases from these peatlands are uncertain as emissions vary with environmental conditions. This study provides the first comprehensive analysis of managed and natural tropical peatland GHG fluxes: heterotrophic (i.

CNCC: an analysis tool to determine genome-wide DNA break end structure at single-nucleotide resolution.

Background: DNA double-stranded breaks (DSBs) are potentially deleterious events in a cell. The end structures (blunt, 3'- and 5'-overhangs) at DSB sites contribute to the fate of their repair and provide critical information concerning the consequences of the damage. Therefore, there has been a recent eruption of DNA break mapping and sequencing methods that aim to map at single-nucleotide resolution where breaks are generated genome-wide.

Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis.

Objectives: A previous individual participant data meta-analysis (IPDMA) identified differences in major depression classification rates between different diagnostic interviews, controlling for depressive symptoms on the basis of the Patient Health Questionnaire-9. We aimed to determine whether similar results would be seen in a different population, using studies that administered the Edinburgh Postnatal Depression Scale (EPDS) in pregnancy or postpartum.

Methods: Data accrued for an EPDS diagnostic accuracy IPDMA were analysed.

Statins affect human glioblastoma and other cancers through TGF-β inhibition.

The cholesterol-lowering statins have known anti-cancer effects, but the mechanisms and how to utilize statins in oncology have been unclear. We noted in the CellMiner database that statin activity against cancer lines correlated with higher expression of TGF-β target genes such as and . This prompted us to assess whether statins affected TGF-β activity in glioblastoma (GBM), a cancer strongly influenced by TGF-β and in dire need of new therapeutic approaches.

Soil heterotrophic respiration assessment using minimally disturbed soil microcosm cores.

Ex-situ measurement of soil respiration is usually done with highly disturbed samples that may confound the interpretation and extrapolation of results. We have developed a lab respiration assessment method that better simulates field conditions and allows efflux estimations based on soil surface area. First, intact soil cores are extracted in the field and transferred to the lab.

Elevated seawater temperature, not CO, negatively affects post-spawning adult mussels () under food limitation.

Pre-spawning blue mussels () appear sensitive to elevated temperature and robust to elevated CO; however, the effects of these stressors soon after investing energy into spawning remain unknown. Furthermore, while studies suggest that elevated CO affects the byssal attachment strength of from southern latitudes, CO and temperature impacts on the byssus strength of other species at higher latitudes remain undocumented. In a 90 day laboratory experiment, we exposed post-spawning adult blue mussels () from Atlantic Canada to three CO levels (CO ~625, 1295 and 2440 μatm) at two different temperatures (16°C and 22°C) and assessed energetic reserves on Day 90, byssal attachment strength on Days 30 and 60, and condition index and mortality on Days 30, 60 and 90.