Evaluation of the impact of HMS Plus on postoperative blood loss compared with ACT Plus in cardiac surgery.

Background: The standardized management of anticoagulation during the cardiopulmonary bypass seems inaccurate because of patients and surgeries variability. This study evaluates if an individualized management of heparin and protamine guided by the HMS Plus system during cardiopulmonary bypass could reduce postoperative blood loss.

Methods: We conducted a prospective, controlled, unblinded, single-center study.