Medical edema protection--clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study.

In a randomized placebo controlled parallel double blind study on 40 patients suffering from venous edema in chronic deep vein incompetence, the edema-reducing effect of horse chestnut seed extract vs. placebo, being the main test variable, was demonstrated by hydroplethysmography to be statistically significant. In addition, measurements of leg volume under aggravated conditions (edema provocation) were conducted, which yielded the same results.

Status of patients seven years after completion of the hypertension detection and follow-up program in Evans County, Georgia.

The Evans County, Georgia, cohort of the Hypertension Detection and Follow-up Program (HDFP) was reexamined seven years after termination of the trial in 1979. Of the 510 survivors, 91 percent of the black and 91 percent of the white hypertensive subjects were evaluated by blood pressure (BP) levels, electrocardiograms (ECG), height-weight measurements, and questionnaire. The HDFP had treated a randomly selected half of the patients in an intensive stepped care (SC) program and the other half was referred to usual care (RC).

[Therapeutic use of lowering blood pressure, especially in mild hypertension. Results of a hypertension detection and treatment program].

The results of the Hypertension Detection and Follow-up Program (HDFP), one of the largest hypertension intervention trials will be reported. 5,485 hypertensives received systematic antihypertensive drug therapy (stepped care) and 5,455 were referred to community medical therapy (referred care) with less intensive treatment. In contrast to other hypertension intervention studies, HDFP did not have any exclusion criteria.

[Peripheral venous tolerance of a hyperosmolar basic solution].

A controlled open clinical trial was carried out to compare the peripheral venous tolerance of patients receiving a hyperosmolar basic nutrition solution (3% amino acids, carbohydrates and electrolytes, 806 mosm/l) with that of patients receiving an isoosmolar electrolyte solution (299 mosm/l). 13 patients received the basic solution, 11 the electrolyte solution. The study was terminated after 4 days.

[Indications for surgery of carotid artery stenosis with contralateral carotid occlusion].

In a retrospective study the course of 69 patients of the Surgery Department of the University of Heidelberg (66 men, 3 women, mean age 60 years) with carotid artery stenosis with contralateral carotid occlusion has been reported. 10% of the patients with carotid artery stenosis had a contralateral occlusion. Corresponding to the side of occlusion most patients had a preoperative neurological stage IV (55%, 19% stage II, 26% stage I) and corresponding to the side of stenosis most patients had a stage I (57%, 28% stage II, 4% stage III, 12% stage IV).

[Gunshot injuries in peacetime and their therapy].

Between 1976 and 1982 46 patients with gunshot injuries (43 m., 3 f.) were seen at the University of Heidelberg Department of Surgery.

[Peripheral arterial vasoocclusive disease: no absolute contraindication to beta receptor blockers (author's transl)].

An initial dosis of 40 mg followed by 40 mg propranolol (Dociton) t.i.d.

[The effects of nicotine on the circulation and metabolism after cigarette smoking with reference to the plasma levels of nicotine and COHb (author's transl)].

The effects after smoking cigarettes with different nicotine content (1.5 mg and 0.08 mg nicotine/cigarette) were investigated in 6 healthy habitual smokers.

The influence of increased dietary linoleate on essential hypertension in man.

A pilot study testing the hypothesis of a blood pressure lowering effect of polyunsaturated fatty acids was conducted in Evans County, Georgia. A moderate increase of dietary linoleic acid significantly decreased diastolic blood pressure in eight borderline hypertensives who were otherwise healthy, within four weeks. The change was not due to a reduced sodium content of the diet.