[Extramedullary blast transformation in chronic granulocytic leukemia].

A patient with Ph1(Philadelphia chromosome) positive chronic granulocytic leukemia and extramedullary blast transformation (crisis) in lymph nodes of neck and axillae which appeared after 4-year of treatment with busulfan is presented. Biopsy of lymph node and histopathological examination showed lymphoblastic infiltration. The patient was treated with radiotherapy and chemotherapy with protocol COP.

[Acute lymphoblastic leukemia in refractory anemia with "ringed" sideroblasts].

The paper deals with the progression of idiopathic refractory sideroblastic anaemia (IRSA) and its transformation to acute B lymphoblastic leukaemia (ALL). Attention is paid to haematological changes prior to leukaemia development. Acute leukaemia was best expressed in this patient by severe deterioration of dyserythropoiesis, leukopenia, and by an increase of blasts in the bone marrow over 5%.

[Orbital lymphomas].

Lymphomas are relatively rare in the orbit: only about 8-11% of all orbital tumours. The most common histological type is diffuse well-differentiated lymphocytic lymphoma (DWDLL--Rappaport's classification)--70%. Orbital lesions are always curable by radiotherapy, but in some 40% of these patients local recurrence or dissemination occur.

[Disseminated zygomycosis in patients with acute leukemia].

The authors present two patients with acute myeloid leukaemia and pulmonary-disseminated form of zygomycosis developed during the period of bone marrow aplasia. Diagnosis was established on necropsy on the basic of the patho-histological finding of wide, short and nonseptate hyphe with irregular branching. Hyphe were clearly recognized on Gomori methenamine Silver stained preparations.

[Accessory spleen causing recurrent idiopathic thrombocytopenic purpura (case report)].

Idiopathic thrombocytopenic purpura is an autoimmune disease in which macrophages of reticuloendothelial system, mainly in the spleen, remove platelets covered by autoantibodies from circulation. By removing the spleen 60-80% of patients are cured. Partial remission is achieved in 10-20% of cases.

Neutrophil alkaline phosphatase activity in the urinary neutrophils of a patient with chronic myelogenous leukemia.

We report here a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) in chronic phase in whom the alkaline phosphatase activity of neutrophils in the peripheral blood was low while at the same time the alkaline phosphatase content of neutrophils present in the urine was elevated. This observation provides independent clinical support for the recent experimental finding that an extrinsic factor (granulocyte colony-stimulating factor) controls alkaline phosphatase expression in human neutrophils.

Dysmegakaryocytopoiesis and thrombocytosis in a patient with acute myelomonocytic leukemia and long evolution.

A patient with acute myelomonocytic leukemia (M4), dysmegakaryocytopoiesis and thrombocytosis is presented. Immunophenotyping and blast colony assay showed the presence of blasts with IaDr, CD 33 and CD 14 antigens. Cytogenetic analysis and level of thrombopoietin were normal.

[Treatment of patients with acute myeloid leukemia--use of Toronto criteria in evaluation of success in therapy].

Over the period from January 1, 1972 to January 1, 1982, a total of 320 patients with acute myeloblastic leukaemia (AML) was registered in our institution. Only 289 case histories were suitable for analysis. In this paper we present the distribution of patients according to the risk group denomination prepared by the Toronto Leukaemia Study Group of Canada.

[Hereditary factors in the etiology of chronic lymphocytic leukemia].

Leukocyte counts, hemoglobin concentration, PAS positivity index in lymphocytes, leukocyte alkaline phosphatase, karyotype, HLA phenotype as wall as the quality of the cellular and humoral immunity have been studied in 45 patients with chronic lymphocytic leukemia (CLL) and in 103 their closest relatives (sibs, parents). The aim was to detect the possible preleukemic condition in the relatives as a strong propensity towards developing has been previously established in families of patients with CLL. In the CLL patients our studies have confirmed the results of the determination of similar parameters by other authors, namely a higher percentage of PAS+ lymphocytes than normal together with a variety of humoral and cellular immunity disturbances.

[Fibrosarcoma of the pancreas].

Fibrosarcoma of the pancreas is a very rare tumour. Its localisation in any part of the pancreas causes various dominant symptoms. Tumour is often enormously enlarged, very vascular, often with central necrosis and penetration into the gastric wall causing ulcers and bleeding.

[Tuberculosis of the lymph nodes and spleen preceding Hodgkin's disease].

Tuberculosis of the lymph nodes is not rare today. However tuberculosis of the spleen has been very rare even in the past when many patients had suffered from tuberculosis. The appearance of Hodgkin's disease following tuberculosis is an extremely rare condition.

Acute myelomonoblastic leukemia in a patient with multiple myeloma.

A 40-year-old man who developed acute myelomonoblastic leukemia (M4) after 7 years of treatment for multiple myeloma with the alkylating agent melphalan and steroids is presented. Leukemia was treated with courses of adriblastin, cytosine arabinoside, and thioguanin (DAT protocol), with a 8 months' survival.

[Splenectomy in the treatment of idiopathic thrombocytopenic purpura].

During the period from 1985 till 1988, 48 patients with this disease were treated; in 28 patients (58%) conservatively treated with pronisone, immunated with thrombocytes that possessed onkovin, a remission had been achieved. In 20 patients (41%), following an unsuccessful conservative treatment, splenectomy was performed; of whom 14 were female (70%) and 6 were male (30%), with an average age of 36 years (between 20-52 years). Prior to that they were conservatively treated from 1-15 years (on the average 4.