Testing a Multidimensional Factor Structure of the Self-Control Scale.

The Self-Control Scale (SCS) is one of the most widely used measures in the clinical, personality, and social psychology fields. It is often treated as unidimensional, even though no research supports such a unidimensional factor structure. We tested the factor structure in an undergraduate sample as well as a community sample used for additional confirmatory analyses.

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes.

Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking. The Multiple Myeloma Research Foundation's Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study ( NCT01454297 ) is a longitudinal, observational clinical study of newly diagnosed patients with multiple myeloma (n = 1,143) where tumor samples are characterized using whole-genome sequencing, whole-exome sequencing and RNA sequencing at diagnosis and progression, and clinical data are collected every 3 months. Analyses of the baseline cohort identified genes that are the target of recurrent gain-of-function and loss-of-function events.

The immunoglobulin A isotype of the Arabian camel () preserves the dualistic structure of unconventional single-domain and canonical heavy chains.

Introduction: The evolution of adaptive immunity in resulted in the concurrent expression of classic heterotetrameric and unconventional homodimeric heavy chain-only IgG antibodies. Heavy chain-only IgG bears a single variable domain and lacks the constant heavy (C) γ1 domain required for pairing with the light chain. It has not been reported whether this distinctive feature of IgG is also observed in the IgA isotype.

Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells.

Patients with digenic S100A3 and S100A13 mutations exhibited an atypical and progressive interstitial pulmonary fibrosis, with impaired intracellular calcium homeostasis and mitochondrial dysfunction. Here we provide direct evidence of a causative effect of the mutation on receptor mediated calcium signaling and calcium store responses in control cells transfected with mutant S100A3 and mutant S100A13. We demonstrate that the mutations lead to increased mitochondrial mass and hyperpolarization, both of which were reversed by transfecting patient-derived cells with the wild type S100A3 and S100A13, or extracellular treatment with the recombinant proteins.

Relative bioavailability of budesonide/glycopyrrolate/formoterol fumarate triple therapy delivered using next generation propellants with low global warming potential.

Introduction: The climate crisis poses an immediate threat to human health and well-being, demanding urgent adaptions across sectors, including healthcare. The development of pressurized metered dose inhalers (MDIs) with greater sensitivity to the climate emergency using novel propellants with lower global warming potentials (GWPs), but comparable pharmacokinetic (PK) parameters to currently marketed MDIs, is a vital step toward reducing the impact of healthcare for respiratory disorders on climate change. This study evaluated the relative bioavailabilities of the individual components of a fixed-dose combination of budesonide/glycopyrrolate/formoterol fumarate (BGF) 160/9/4.

OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic.

Background: The COVID-19 pandemic has disrupted healthcare activity across a broad range of clinical services. The NHS stopped non-urgent work in March 2020, later recommending services be restored to near-normal levels before winter where possible.

Aim: To describe changes in the volume and variation of coded clinical activity in general practice across six clinical areas: cardiovascular disease, diabetes, mental health, female and reproductive health, screening and related procedures, and processes related to medication.

Correct use and ease-of-use of placebo ELLIPTA dry-powder inhaler in adult patients with chronic obstructive pulmonary disease.

Background: Inhaler technique errors are common in chronic obstructive pulmonary disease (COPD) treatment, potentially leading to poor disease management. Our pooled analysis approach assessed correct use and ease-of-use of a placebo ELLIPTA dry-powder inhaler (DPI) in patients with COPD.

Methods: Adults with COPD from open-label/non-blinded studies evaluating a placebo ELLIPTA DPI and reporting outcomes of correct use (based on the ELLIPTA DPI patient information leaflet [PIL]) and/or ease-of-use were included.

Transcriptomal Insights of Heart Failure from Normality to Recovery.

Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more precise treatments. To attain a clearer picture of this, we studied transcriptome changes in a chronic progressive HF model.

The novel frontal alpha asymmetry factor and its association with depression, anxiety, and personality traits.

Frontal alpha asymmetry (FAA) is widely examined in EEG research, yet a procedural consensus on its assessment is lacking. In this study, we tested a latent factorial approach to measure FAA. We assessed resting-state FAA at broad, low, and high alpha bands (8-13; 8-10.

Does Machiavellianism meaningfully differ from psychopathy? It depends.

Machiavellianism is a personality construct characterized by cynicism, callousness, and skillful manipulation of others to achieve personal gains. We review the Machiavellianism literature with a particular focus on its measurement alongside narcissism and psychopathy in the so-called "Dark Triad" (DT). We discuss criticisms of Machiavellianism on the grounds of insufficient construct validity as well as its virtual indistinguishability from psychopathy when assessed by commonly used instruments.

Toward allogenizing a xenograft: Xenogeneic cardiac scaffolds recellularized with human-induced pluripotent stem cells do not activate human naïve neutrophils.

The limited availability of human donor organs suitable for transplantation has resulted in ever-increasing patient waiting lists globally. Xenotransplantation is considered a potential option, but is yet to reach clinical practice. Although remarkable progress has been made in overcoming immunological rejection, issues with functionality are still to be resolved.

Pilot Study of a Patient Experience with an ELLIPTA Inhaler Electronic Medication Monitor and Associated Integrated System: A Prospective Observational Study Using the COPD Patient-Powered Research Network.

Background: Electronic medication monitors (EMMs) are associated with decreased rescue inhaler use, symptom burden, and increased medication adherence in asthma. However, the use of EMMs in people with chronic obstructive pulmonary disease (COPD) using the ELLIPTA dry powder inhaler has not been studied.

Methods: This was an open-label, single-arm, prospective observational study of EMMs and associated application (app) use over 12 weeks and up to 24 weeks (April-October 2019) in people with self-reported COPD aged ≥40 years enrolled in the COPD Patient-Powered Research Network, using an ELLIPTA inhaler.

Personality disorders as predictors of intimate partner violence: A meta-analysis.

Despite years of research demonstrating a relation between personality pathology and intimate partner violence (IPV), no meta-analysis has been published examining how well, or poorly, all ten personality disorders (PDs) predict IPV perpetration or victimization, nor has any meta-analysis examined these relations across types of IPV. Therefore, the present study was undertaken to synthesize existing research on the effects of all ten PDs, as well as psychopathy and global PD symptoms, on physical, psychological, and sexual IPV perpetration and victimization. An initial search in PsycINFO, PubMed, and Sociological Abstracts yielded 3988 results.

Peak Inspiratory Flow Rate in COPD: An Analysis of Clinical Trial and Real-World Data.

Background: The influence of peak inspiratory flow (PIF) on dose delivery from dry powder inhalers (DPIs) and association with treatment efficacy in patients with chronic obstructive pulmonary disease (COPD) has not been fully determined. In vitro studies have demonstrated adequate dose delivery through ELLIPTA DPI at PIF ≥30 L/min. This analysis of two clinical trials and a real-world population of COPD patients determined spirometric PIF distribution, and explored the relationship between PIF and outcomes in the trials.

Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice.

Background: The ever-increasing prevalence of diabetes and associated comorbidities serves to highlight the necessity of biologically relevant small-animal models to investigate its etiology, pathology and treatment. Although the C57BL/6 J model is amongst the most widely used mouse model due to its susceptibility to diet-induced obesity (DIO), there are a number of limitations namely [1] that unambiguous fasting hyperglycemia can only be achieved via dietary manipulation and/or chemical ablation of the pancreatic beta cells. [2] Heterogeneity in the obesogenic effects of hypercaloric feeding has been noted, together with sex-dependent differences, with males being more responsive.

Development and Validation of the Super-Short Form of the Five Factor Machiavellianism Inventory (FFMI-SSF).

Previous findings have showed that existing measures of Machiavellianism often fail to distinguish Machiavellianism from another construct in the Dark Triad (i.e., psychopathy) and do not align with theoretical descriptions.

Untangling the Relation Between Narcissistic Traits and Behavioral Aggression Following Provocation Using an FFM Framework.

Work on narcissism has identified two variants: grandiose and vulnerable. The variants share an antagonistic core, but differ in neuroticism and extraversion. The current study explored how the variants relate to behavioral aggression following provocation.

The Importance of Antagonism: Explaining Similarities and Differences in Psychopathy and Narcissism's Relations With Aggression and Externalizing Outcomes.

Psychopathy and narcissism are multidimensional constructs with substantial overlap. Low agreeableness (i.e.

The evaluation of the correct use and ease-of use of the ELLIPTA DPI in children with asthma.

Rationale: Asthma studies show many children use inhalers incorrectly even after instruction. For two age groups of children with asthma, we determined the proportions who used the once-daily ELLIPTA dry-powder inhaler (DPI) correctly, and who found it easy to use.

Methods: This was a multicenter, single-arm, stratified, open-label, placebo study (NCT03478657).

Critical Error Frequency and the Impact of Training with Inhalers Commonly used for Maintenance Treatment in Chronic Obstructive Pulmonary Disease.

Introduction: Training in correct inhaler use, ideally in person or by video demonstration, can minimize errors but is rarely provided in clinics. This open-label, low-intervention study evaluated critical error rates with dry-powder inhalers (DPIs), before and after training, in patients with chronic obstructive pulmonary disease.

Methods: Patients prescribed an inhaled corticosteroid (ICS)/long-acting β-agonist (LABA) (ELLIPTA, Turbuhaler, or DISKUS), long-acting muscarinic antagonist (LAMA)/LABA (ELLIPTA or Breezhaler), or LAMA-only DPI (ELLIPTA, HandiHaler, or Breezhaler) were enrolled.

ELLIPTA Versus DISKUS plus HandiHaler in COPD: A Randomized, Open-Label, Crossover Study in a Clinical Trial Setting.

Background: Inhaler errors among patients with chronic obstructive pulmonary disease (COPD) can reduce treatment efficacy.

Methods: This randomized, open-label, crossover study evaluated correct use of ELLIPTA versus DISKUS plus HandiHaler. Participants with COPD attended at least 3 study visits (Day 1 [Visit 1], Day 28 [Visit 2], and Day 56 [Visit 3]).

Exploring Gender Differences in Machiavellianism Using a Measurement Invariance Approach.

Research suggests that men and women differ on mean levels of Dark Triad personality constructs such as Machiavellianism, but few studies have investigated whether or not these differences are due to actual latent trait differences or bias in measurement. Further, recent research suggests important challenges associated with existing measures of MACH in terms of overlap with psychopathy and matching expert descriptions. The present study took a recently developed measure of Machiavellianism (the Five Factor Machiavellianism Inventory; FFMI), based on the five-factor model, and examined its invariance across gender.

Examining the factor structure and validity of the Triarchic Model of Psychopathy across measures.

The triarchic model of psychopathy proposes 3 distinct trait domains underlying psychopathy: boldness, meanness, and disinhibition. The original (and most widely used) measure developed from this model is the Triarchic Psychopathy Measure (TriPM), which yields a total psychopathy score as well as scores on each of the 3 domains. Recently, researchers have derived several alternative measures from other inventories to assess these 3 domains; however, the purported underlying 3-factor structure of the alternative scales has been relatively untested.