Pediatric tympanoplasty: effect of contralateral ear status on outcomes.

Objective: To assess the prognostic value of different variables on the outcome of pediatric type I tympanoplasty.

Design: Retrospective review of medical records.

Setting: An otolaryngology department in a large urban tertiary care medical center.

Results from an ultrasound-based familial ovarian cancer screening clinic: a 10-year observational study.

Objectives: To assess the use of transvaginal sonography as a screening test for familial ovarian cancer and, secondarily, to determine the value of a family history of malignant disease and the potential role of serum CA 125 levels in the screening procedure.

Methods: Two thousand five hundred self-referred women were studied at the Ovarian Screening Clinic at King's College Hospital, London. These symptom-free women with at least one close relative who had developed ovarian cancer were studied prospectively.

A retrospective examination of mosquito infection on humans infected with Plasmodium falciparum.

A retrospective examination was made of archival data collected between 1940 and 1963 on the infection of mosquitoes with Plasmodium falciparum. Patients were undergoing malariatherapy for the treatment of neurosyphilis. A total of 913 lots of Anopheles quadrimaculatus and An.

Herpes simplex virus gE/gI expressed in epithelial cells interferes with cell-to-cell spread.

The herpes simplex virus (HSV) glycoprotein heterodimer gE/gI plays an important role in virus cell-to-cell spread in epithelial and neuronal tissues. In an analogous fashion, gE/gI promotes virus spread between certain cell types in culture, e.g.

Potential of the Panama strain of Plasmodium vivax for the testing of malarial vaccines in Aotus nancymai monkeys.

Aotus monkeys were infected with a strain of Plasmodium vivax from Panama to determine its potential for the testing of malarial vaccines. After sporozoite inoculation, 3 splenectomized Aotus nancymai that had been infected previously with Plasmodium falciparum and P. vivax had prepatent periods of 13, 15, and 15 days with maximum parasite counts of 12,726/microl, 5,310/microl, and 9,180/microl.

Changes in Hematologic Values During Infection of New World Monkeys With Plasmodium falciparum and P. vivax.

Owl (Aotus sp.) and squirrel (Saimiri sp.) monkeys are used frequently in malaria vaccine trials, during which the animals are monitored daily for parasitemia and general well-being.

Plasmodium malariae infection boosts Plasmodium falciparum gametocyte production.

We analyzed records of malaria therapy patients sequentially or simultaneously inoculated with Plasmodium falciparum and Plasmodium malariae. Gametocyte production was enhanced in P. falciparum by prior or concurrent P.

Extended clearance time after treatment of infections with Plasmodium malariae may not be indicative of resistance to chloroquine.

A retrospective examination was made of archival data on the response of Plasmodium malariae infections in humans to chloroquine. The clearance time for P. malariae was longer than that for P.

A retrospective examination of sporozoite-induced and trophozoite-induced infections with Plasmodium ovale: development of parasitologic and clinical immunity during primary infection.

A retrospective analysis was made of clinical and parasitologic parameters in patients with induced Plasmodium ovale infection to document the initial clinical and parasitologic response and their subsequent development of clinical and parasitologic immunity, and to determine the effect of previous homologous and heterologous malaria on subsequent infection with this parasite. The prepatent periods were relatively uniform. Eight patients injected with sporozoites that had been stored frozen had a median prepatent period of 14 days (range = 14-20 days).

Plasmodium vivax blood-stage dynamics.

We examine the dynamics of parasitemia and gametocytemia reflected in the preintervention charts of 221 malaria-naive U.S. neurosyphilis patients infected with the St.

The intersection of adolescent development and intensive intervention: age-related psychosocial correlates of treatment regimens in the diabetes control and complication trial.

Objective: To provide evidence relevant to developmentally sensitive intervention and prevention of adolescents' psychosocial distress associated with treatment of type 1 diabetes.

Methods: We used self-reports on the Diabetes Quality of Life and SCL-90-R inventories administered at baseline, 1, and 3 years following adolescents' (n = 224) entry into the Diabetes Control and Complications Trial.

Results: Initiation of intensive treatment in early adolescence was associated with increasing school dissatisfaction; initiation in later adolescence resulted in marginal elevations in psychological distress.

Malaria therapy reinoculation data suggest individual variation of an innate immune response and independent acquisition of antiparasitic and antitoxic immunities.

Malaria therapy reinoculation data were examined for the possible detection of effects attributable to stable individual host-specific factors, through correlation between descriptive variables of first and second infections. Such an effect was demonstrated with respect to the first local maximum of the asexual parasite density, i.e.

Infection of Aotus and Saimiri monkeys with Plasmodium gonderi.

Attempts were made to infect 4 species of New World monkeys (Saimiri boliviensis, Aotus nancymai, A. vociferans, A. azarae boliviensis) with Plasmodium gonderi, a malaria parasite of African monkeys.

Experimental infection of Anopheles farauti with different species of Plasmodium.

Studies were conducted to determine the susceptibility of Anopheles farauti to different species and strains of Plasmodium. Mosquitoes were infected by feeding on animals or cultures infected with different strains of P. vivax, P.

Outcome of expectant management of spontaneous first trimester miscarriage: observational study.

Objectives: To evaluate the uptake and outcome of expectant management of spontaneous first trimester miscarriage in an early pregnancy assessment unit.

Participants: 1096 consecutive patients with a diagnosis of spontaneous first trimester miscarriage.

Methods: Each miscarriage was classified as complete, incomplete, missed, or anembryonic on the basis of ultrasonography.

Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection.

A retrospective analysis was performed of parasite count data recorded from the first 7 days of blood or mosquito transmitted Plasmodium falciparum infections given for the treatment of neurosyphilis in the USA before 1963. The objective of this study was to characterize initial growth dynamics before host defences have significant effects on the infecting parasite population. Of the 328 patients' data available for analysis, 83 were excluded because they had received anti-malarial treatment during the first 7 days of the patent infection.

Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line.

Immunity to Plasmodium falciparum in African children has been correlated with antibodies to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant gene family expressed on the surface of infected red cells. We immunized Aotus monkeys with a subregion of the Malayan Camp variant antigen (MCvar1) that mediates adhesion to the host receptor CD36 on the endothelial surface and present data that PfEMP1 is an important target for vaccine development.

Adaptation of a strain of Plasmodium vivax from India to New World monkeys, chimpanzees, and anopheline mosquitoes.

A strain of Plasmodium vivax from India was adapted to develop in splenectomized Saimiri boliviensis, Aotus lemurinus griseimembra, A vociferans, A. nancymai, A. azarae boliviensis, hybrid Aotus monkeys, and splenectomized chimpanzees.

Antibodies to Plasmodium vivax transmission-blocking vaccine candidate antigens Pvs25 and Pvs28 do not show synergism.

Transmission-blocking vaccines against malaria parasites target molecules expressed by sexual stage parasites to elicit antibodies that prevent the infection of the mosquito vector. Pvs25 and Pvs28, expressed on the surface of ookinetes, are potential candidates for such a vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunized animals. To improve the ability to induce transmission-blocking antibodies, Pvs25 and Pvs28 were produced as a single fusion protein by the yeast Saccharomyces cerevisiae.

The coherence of dyadic behavior across parent-child and romantic relationships as mediated by the internalized representation of experience.

Attachment theory suggests, first, that patterns of dyadic behavior cohere across salient relationships and, second, that such linkages are mediated by working models, defined as cognitive/emotional representations of relationships abstracted from dyadic experience. In this longitudinal study, adolescents' (age 19) Adult Attachment Interview (AAI) coherence ratings and classifications (e.g.