Publications by authors named "Collins Kebenei"
Article Synopsis
- - The study focused on investigating the genotypic diversity of multidrug-resistant (MDR) *Typhi* in symptomatic and asymptomatic children in Nairobi, Kenya, specifically targeting those below 16 years old through testing at four health facilities.
- - Out of 90 *Typhi* isolates sequenced, 67% were confirmed as *Typhi*, with the most common genotype being 4.3.1 (sequence Type 1), and 65% of these strains carried plasmids associated with antibiotic resistance.
- - The findings revealed a high prevalence of point mutations that reduce susceptibility to quinolones, highlighting the urgency of implementing typhoid conjugate vaccines in vulnerable populations to combat the spread of MDR *
Background: The emergence and persistence of multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) infections is a significant global health problem. The carrier state of typhoid makes it prudent to conduct routine surveillance for both acute cases and carriers especially those caused by MDR S.
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- Nontyphoidal Salmonella (NTS) is a major cause of invasive infections among children under 5 in sub-Saharan Africa, with asymptomatic fecal shedding possibly facilitating human-to-human transmission, particularly in low-resource areas.
- This study involved 3,293 children and healthy individuals in Nairobi, revealing a 1.52% prevalence of NTS, and 31% of children with a previous NTS infection exhibited asymptomatic shedding post-treatment, with some shedding the same strain as during their illness.
- The findings suggest a likely connection between asymptomatic shedding and the transmission of NTS, supporting the idea that introducing a vaccine could help mitigate these infections in vulnerable populations.*