Publications by authors named "Collins A Onyeto"
Objective: Aqueous extract of unripe fruit is commonly used for the treatment of ulcers in eastern Nigeria. This study aimed to assess the acute and subacute effects of an aqueous extract of unripe fruit on male and female fertility in rats.
Methods: Aqueous extracts obtained by maceration were analyzed for acute and subacute toxicity and for the presence of phytochemical constituents using standard procedures.
Background: , commonly called '', a versatile plant used locally to treat malaria fever in some parts of sub-Saharan Africa was investigated for anti-plasmodial and anti-inflammatory activities.
Objective: The study was designed to evaluate the antiplasmodial as well as anti-inflammatory activities of whole extract and cyclotide-rich fraction of .
Method: The dichloromethane-methanol extract (ODE) of the plant, was investigated for suppressive and curative antiplasmodial activities against in mice.
Article Synopsis
- The study investigates the antiplasmodial effects of the leaf extract from Landolphia owariensis, traditionally used in southeast Nigeria for malaria treatment, on Plasmodium berghei-infected mice.
- Results showed significant suppression of parasitemia and improved survival rates in treated mice, with the methanol fraction demonstrating the highest antimalarial activity and low toxicity.
- The findings support the medicinal use of L. owariensis by identifying key phytochemicals like alkaloids and flavonoids responsible for its effectiveness against malaria.
Background: Earlier studies in our laboratory demonstrated the anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract, a herbal remedy used to treat disorders of inflammation. This study was undertaken to evaluate its anti-inflammatory mechanism(s).
View Article and Find Full Text PDFObjective: To investigate the safety profile of Annona senegalensis (A. senegalensis).
Methods: Dried powdered root-bark of A.