Publications by authors named "Collin V Brummel"
Article Synopsis
- Head and neck squamous cell carcinomas (HNSCC) have high treatment-related complications and poor survival rates, particularly in recurrent or metastatic cases, with PD-1/PD-L1 inhibitors now being a primary treatment option.
- A study identified 335 genes that enhance PD-L1 expression in HNSCC cells, validating five specific genes (FGF6, IL17A, CD300C, KLR1C, NFKBIA) as key drivers, with FGF ligand being a significant factor in this regulation.
- The research suggests that FGF signaling promotes immune evasion through PD-L1 upregulation, indicating potential for new combination therapies to improve treatment effectiveness against
Background: Human papillomavirus (HPV) is a well-established driver of malignant transformation at a number of sites, including head and neck, cervical, vulvar, anorectal, and penile squamous cell carcinomas; however, the impact of HPV integration into the host human genome on this process remains largely unresolved. This is due to the technical challenge of identifying HPV integration sites, which includes limitations of existing informatics approaches to discovering viral-host breakpoints from low-read-coverage sequencing data.
Methods: To overcome this limitation, the authors developed SearcHPV, a new HPV detection pipeline based on targeted capture technology, and applied the algorithm to targeted capture data.
Background: There are limited treatment options for unresectable recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Vascular endothelial growth factor is of significant interest for targeted therapy in R/M HNSCC because of its central role in tumorigenesis and immunosuppression. Axitinib is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR) 1 , VEGFR2, VEGFR3, platelet-derived growth factor receptor, as well as c-kit and offers such an approach.
View Article and Find Full Text PDFBackground: The molecular drivers of human papillomavirus-related head and neck squamous cell carcinoma (HPV + HNSCC) are not entirely understood. This study evaluated the relationship between HPV integration, expression of E6/E7, and patient outcomes in p16+ HNSCCs.
Methods: HPV type was determined by HPV PCR-MassArray, and integration was called using detection of integrated papillomavirus sequences polymerase chain reaction (PCR).