Publications by authors named "Colleen M Hayes"
Hepatol Commun
January 2025
Article Synopsis
- Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are liver diseases that damage bile ducts, leading to bile accumulation, liver injury, and increased risk of liver failure; current treatments are limited, especially for PSC.
- Ursodeoxycholic acid is the first-line treatment for PBC, but many patients do not respond fully, indicating a need for better therapies; pruritus (itching) is a common and severe symptom due to cholestasis that is often inadequately treated.
- The review examines the use of PPAR agonists, a type of medication that targets liver metabolism, as potential second-line treatments for PBC and PSC, highlighting recent FDA approvals for
Article Synopsis
- * There is a significant need for alternative treatments, particularly for patients who do not respond well to current therapies, as untreated conditions can progress to severe liver damage and potentially require transplants.
- * Recent research has focused on targeting nuclear hormone receptors, especially the peroxisome proliferator-activated receptor (PPAR), as potential adjunct therapies; PPAR agonists have shown promise in alleviating symptoms in PBC and PSC, with
