Prolonged spaceflight can lead to muscle atrophy, and partial gravity similar to the Moon's surface may worsen this, especially when combined with space radiation exposure.
A study was conducted on mice to investigate the effects of partial weight-bearing (simulating Lunar gravity) and radiation on muscle mass and protein synthesis.
Results showed that partial weight-bearing decreased muscle mass but radiation exposure did not further impact muscle mass, although some changes in protein synthesis and muscle fiber types were observed.