Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders.

Objectives:   Abnormalities in auditory steady state response (ASSR) at gamma range frequencies have been found in bipolar disorder, but the relationship of these neurophysiological disturbances to clinical factors has not been well characterized. We therefore evaluated the ASSR in bipolar disorder and examined its sensitivity to clinical symptoms, cognitive function, and pharmacological treatment.

Methods:   A total of 68 patients with bipolar disorder and 77 control participants were evaluated.