Synopsis of recent research by authors named "Coline Moulin"
- Coline Moulin's research primarily focuses on combining oncolytic virotherapy with immune checkpoint blockade (ICB) to enhance anti-tumor immunity, particularly in the context of pancreatic ductal adenocarcinoma (PDAC) which is resistant to traditional therapies.
- One key finding from Moulin's studies is that oncolytic measles vaccines can effectively reshape the tumor immune environment and increase tumor-specific T cell memory, suggesting a synergistic effect with PD-1 blockade to overcome immune exclusion in resistant tumors.
- Moulin's investigations also explore the relationship between extracellular vesicles (EVs) and viruses, highlighting their intertwined nature in manipulating immune responses and potential roles in both promoting and regulating viral infections.
