Publications by authors named "Colin W Pritchard"
Background: Doctors are poor at help-seeking, particularly for mental ill health; attitudes of colleagues reflecting stigmatisation may be important factors influencing decisions to seek support.
Aims: This article focuses on doctors' attitudes to depression rather than mental illness in general. It seeks to determine the extent to which doctors perceive depression is stigmatised within the medical profession and whether the level of perceived stigma affects patterns of help-seeking behaviour.
Article Synopsis
- Alzheimer's disease patients often experience behavioral and psychological symptoms of dementia (BPSD), and genetic factors may influence these symptoms, with a focus on the dopamine transporter (DAT1) gene in this study.
- The study analyzed data from 395 Alzheimer's patients to explore the relationship between their symptoms and the DAT1 gene's variable number tandem repeat (VNTR) polymorphism.
- Results showed a potential link between specific gene alleles and symptoms like irritability and aberrant motor behavior, though these findings need further validation in larger groups.
Background/aims: Alzheimer disease (AD) patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in AD has been demonstrated. This is an investigation of whether the linked polymorphic region and variable number tandem repeat variants of the serotonin transporter (SERT) are associated with BPSD.
View Article and Find Full Text PDFObjective: Alzheimer's disease (AD) patients suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in AD has been demonstrated. Polymorphisms within serotonin receptors 5HT(2A) and 5HT(2C) have been previously investigated in a few interesting studies reviewed here, however, their role remains unclear.
View Article and Find Full Text PDFGenome scans in sporadic Alzheimer's disease (AD) have revealed a possible susceptibility locus on chromosome 12. The low density lipoprotein receptor related protein (LRP1) gene lies within this area of linkage. Eighteen previous AD case-control studies have investigated the C766T polymorphism in LRP1 with conflicting results, including a protective effect on AD of the T allele, an increased susceptibility towards AD with both the C and T alleles, or no association at all.
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