Publications by authors named "Colin Staab"
Loss-of-function (LoF) variants in the lipid transporter ABCA7 significantly increase the risk of Alzheimer's disease (odds ratio ∼2), yet the pathogenic mechanisms and the neural cell types affected by these variants remain largely unknown. Here, we performed single-nuclear RNA sequencing of 36 human samples from the prefrontal cortex of 12 ABCA7 LoF carriers and 24 matched non-carrier control individuals. ABCA7 LoF was associated with gene expression changes in all major cell types.
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- Researchers have developed a cutting-edge brain-like 3D hydrogel model that mimics important aspects of human brain function, including neuron and immune cell interactions, to better study neurological diseases.
- This integrated model, called miBrain, includes all six major types of brain cells and demonstrates key features like neuronal activity, functional connectivity, and myelin production.
- The model is being used to investigate Alzheimer's disease, revealing how astrocytes might influence neuronal tau pathology and dysfunction through communication with microglia.