Publications by authors named "Colin Small"

Article Synopsis
  • Cell-free DNA (cfDNA) from blood can be used for cancer diagnosis, treatment guidance, and monitoring, but detecting mutations in cfDNA is difficult due to low tumor levels.
  • The new computational method cfSNV has been developed to more effectively identify these mutations in cfDNA, outperforming traditional methods that only work well with solid tumor samples.
  • The user-friendly cfSNV package allows researchers, even those with limited computational skills, to analyze cfDNA efficiently on both local and high-performance computing systems, with mutation detection taking about 3 hours on a capable server.
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Global-scale energy flow throughout Earth's magnetosphere is catalyzed by processes that occur at Earth's magnetopause (MP). Magnetic reconnection is one process responsible for solar wind entry into and global convection within the magnetosphere, and the MP location, orientation, and motion have an impact on the dynamics. Statistical studies that focus on these and other MP phenomena and characteristics inherently require MP identification in their event search criteria, a task that can be automated using machine learning so that more man hours can be spent on research and analysis.

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Recently, efforts to model and assess a system's resilience to disruptions due to environmental and adversarial threats have increased substantially. Researchers have investigated resilience in many disciplines, including sociology, psychology, computer networks, and engineering systems, to name a few. When assessing engineering system resilience, the resilience assessment typically considers a single performance measure, a disruption, a loss of performance, the time required to recover, or a combination of these elements.

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