Traumatic and spontaneous scleral rupture and uveal prolapse in osteogenesis imperfecta.

Three cases of severe globe injuries due to scleral fragility in osteogenesis imperfecta patients between the ages of 4 and 15 years are reported. Patient 1 had complete loss of vision. Patients 2 and 3 suffered non-sight-threatening scleral perforation.

Ahmed glaucoma valve implants in the pediatric population: the use of magnetic resonance imaging findings for surgical approach to reoperation.

Purpose: To describe and to evaluate a novel application of magnetic resonance imaging (MRI) in determining the Ahmed glaucoma valve (AGV) function after implantation.

Methods: Retrospective interventional case series of all surgical glaucoma patients in one practice were identified and orbital MRI series were performed. Orbital MRI findings were evaluated in all children who had undergone Ahmed glaucoma valve insertion.

Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia: a 1-year, multicenter, double-masked, placebo-controlled parallel study.

Objective: To evaluate the safety and efficacy of the relatively selective M(1) antagonist pirenzepine hydrochloride in slowing the progression of myopia in school-aged children.

Methods: This was a parallel-group, placebo-controlled, double-masked study in healthy children, aged 8 to 12 years, with a spherical equivalent of -0.75 to -4.

Ocular findings in Jacobsen syndrome.

Purpose: To discuss the ophthalmic findings and their clinical significance in 10 new cases of Jacobsen syndrome (mental retardation, craniofacial anomalies, congenital heart defects, and blood dyscrasias) and to review the ophthalmic findings in all previously reported cases in the literature.

Methods: Ten new cases of Jacobsen syndrome were collected and studied prospectively for detection of abnormal ophthalmologic examination findings. A total of 63 previously reported cases were identified from Medline and analyzed for ophthalmologic abnormalities.