Publications by authors named "Colin J Mitchell"

The integration of light sources on a photonic platform is a key aspect of the fabrication of self-contained photonic circuits with a small footprint that does not have a definitive solution yet. Several approaches are being actively researched for this purpose. In this work we propose optoelectronic tweezers for the manipulation and integration of light sources on a photonic platform and report the positional and angular accuracy of the micromanipulation of standard Fabry-Pérot InP semiconductor laser die.

View Article and Find Full Text PDF

The nonlinear absorption properties of a germanium-on-silicon waveguide have been characterized across the two-photon absorption (TPA) transmission window. The results show that the TPA parameters in germanium waveguides are much stronger than the peak values in silicon, in good agreement with selected measurements conducted in bulk materials. Exploiting the large nonlinear absorption near the bandedge, efficient all-optical modulation is achieved with a modulation depth of ∼8  dB and a response time <5  ps.

View Article and Find Full Text PDF

All-optical modulation has been demonstrated in a germanium-on-silicon rib waveguide over the mid-infrared wavelength range of 2-3 μm using a free-carrier absorption scheme. Transmission measurements have shown the waveguides to have low propagation losses that are relatively independent of wavelength out to 3.8 μm, indicating that the modulation could be extended further into the mid-infrared region for applications in sensing and spectroscopy.

View Article and Find Full Text PDF

Iron homeostasis is achieved by regulating the intestinal absorption of the metal and its recycling by macrophages. Iron export from enterocytes or macrophages to blood plasma is thought to be mediated by ferroportin under the control of hepcidin. Although ferroportin was identified over a decade ago, little is understood about how it works.

View Article and Find Full Text PDF

We report observations of dusty clouds in Saturn's rings, which we interpret as resulting from impacts onto the rings that occurred between 1 and 50 hours before the clouds were observed. The largest of these clouds was observed twice; its brightness and cant angle evolved in a manner consistent with this hypothesis. Several arguments suggest that these clouds cannot be due to the primary impact of one solid meteoroid onto the rings, but rather are due to the impact of a compact stream of Saturn-orbiting material derived from previous breakup of a meteoroid.

View Article and Find Full Text PDF
Article Synopsis
  • Recent studies indicate that the protein Zip14 enhances the uptake of zinc and nontransferrin-bound iron (NTBI) in cells.
  • Experiments using Xenopus laevis oocytes showed Zip14 acts as a specific transporter for ferrous iron (Fe(2+)) and has specific properties like saturation and temperature dependence.
  • Additionally, Zip14 can also facilitate the uptake of other metal ions such as cadmium (Cd(2+)), manganese (Mn(2+)), and zinc (Zn(2+)), with different inhibitory profiles for each metal, highlighting its complexity as a metal-ion transporter.
View Article and Find Full Text PDF