Demonstration and evaluation of commercial and municipal equipment for urban biological decontamination.

Large-scale biological contamination incidents pose unique yet significant challenges to remediation operations. Previous incidents have demonstrated the utility of readily available commercial and municipal equipment for conducting remediation tasks. Preidentification and evaluation of such equipment could reduce lag time for response initiation and enhance overall response effectiveness and efficiency.

YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling.

Relapsed neuroblastomas are enriched with activating mutations of the RAS-MAPK signaling pathway. The MEK1/2 inhibitor trametinib delays tumor growth but does not sustain regression in neuroblastoma preclinical models. Recent studies have implicated the Hippo pathway transcriptional coactivator protein YAP1 as an additional driver of relapsed neuroblastomas, as well as a mediator of trametinib resistance in other cancers.

Synthesis and Characterization of a Two Stage, Nonlinear Photobase Generator.

Amine photobase generators (PBGs) are uncommon yet useful compounds. Rarer still are examples of PBGs that are active at visible wavelengths. We report the synthesis and characterization of new photolabile amine protecting groups that are active under visible light.

UK experience in the monitoring and control of lead in drinking water.

At the zonal scale (e.g. a city or town), random daytime (RDT) sampling succeeded in demonstrating both the need for corrective action and the benefits of optimised orthophosphate dosing for plumbosolvency control, despite initial concerns about sampling reproducibility.

Low-Loss Optical Waveguides for the Near Ultra-Violet and Visible Spectral Regions with Al(2)O(3) Thin Films from Atomic Layer Deposition.

In this work, we report low-loss single-mode integrated optical waveguides in the near ultra-violet and visible spectral regions with aluminum oxide (Al(2)O(3)) films using an atomic layer deposition (ALD) process. Alumina films were deposited on glass and fused silica substrates by the ALD process at substrate/chamber temperatures of 200 °C and 300 °C. Transmission spectra and waveguide measurements were performed in our alumina films with thicknesses in the range of 210 - 380 nm for the optical characterization.

Computational modelling methods for assessing the risks from lead in drinking water.

Computational modelling methods have been used to predict the risks from lead in drinking water across a simulated supply zone, for a range of plumbosolvency conditions and a range of extents of occurrence of houses having a lead pipe, on the basis of five risk benchmarking methods. For the worst case modelled (very high plumbosolvency and 90% houses with a lead pipe) the percentage of houses at risk in the simulated zone ranged from 34.1 to 73.

Computational modelling to investigate the sampling of lead in drinking water.

The monitoring of lead in drinking water is beset by difficulties relating to the inherent temporal variation of lead emissions at individual premises. Such difficulties are compounded by spatial variation when considering an entire water supply area (e.g.

A biomechanical investigation of a single-limb squat: implications for lower extremity rehabilitation exercise.

Context: Single-limb squats on a decline angle have been suggested as a rehabilitative intervention to target the knee extensors. Investigators, however, have presented very little empirical research in which they have documented the biomechanics of these exercises or have determined the optimum angle of decline used.

Objective: To determine the involvement of the gastrocnemius and rectus femoris muscles and the external ankle and knee joint moments at 60 degrees of knee flexion while performing a single-limb squat at different decline angles.