Publications by authors named "Colin Hall"

This review paper explores the acceptance of renewable energy (RE) installations and projects, focusing on the perspectives of local residents and tourists. While previous research has extensively examined community acceptance of RE, limited attention has been given to tourists' acceptance in tourist destinations. Despite extensive research, significant gaps persist, particularly regarding tourists' acceptance of RE installations.

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The present paper aims to provide an overview of the current state-of-the-art mechanical surface modification technologies and their response in terms of surface roughness, surface texture, and microstructural change due to cold work-hardening, affecting the surface integrity and corrosion resistance of different Mg alloys. The process mechanics of five main treatment strategies, namely, shot peening, surface mechanical attrition treatment, laser shock peening, ball burnishing, and ultrasonic nanocrystal surface modification, were discussed. The influence of the process parameters on plastic deformation and degradation characteristics was thoroughly reviewed and compared from the perspectives of surface roughness, grain modification, hardness, residual stress, and corrosion resistance over short- and long-term periods.

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Currently available anti-erosive agents only provide partial protection, emphasizing the need to enhance their performance. By characterizing erosive enamel wear at the nanoscale, the aim of this in vitro study was to assess the anti-erosive effects of SnF and CPP-ACP both individually and synergistically. Erosion depths were assessed longitudinally on 40 polished human enamel specimens after 1, 5, and 10 erosion cycles.

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Although the impact of entrepreneurs' social identity on successful entrepreneurship has attracted much scholarly attention, it is often to evaluate successful entrepreneurship through direct channel to financial performance. Recently, there is a growing body of researches beginning to pay attention to the impact of entrepreneurs' social identity on corporate social responsibility (CSR) regarded as indirect social aspect channel to successful entrepreneurship. However, little is known regarding how entrepreneurs' Darwinian social identity affects CSR, which in turn, affects business performance.

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Plasma-polymerised tetramethyldisiloxane (TMDSO) films are frequently applied as coatings for their abrasion resistance and barrier properties. By manipulating the deposition parameters, the chemical structure and thus mechanical properties of the films can also be controlled. These mechanical properties make them attractive as energy adsorbing layers for a range of applications, including carbon fibre composites.

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The fast degradation and consequent loss of mechanical integrity is a major problem of biodegradable Mg alloy, which limits its clinical viability. This paper presents the influence of a synergistic approach combining deep ball burnishing and hydroxyapatite (HA) coating on biomechanical integrity, degradation and immune response of Mg alloy (AZ31B). The burnishing resulted in smooth surface topography, increased hardness from 0.

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Silicon has been considered a good candidate for replacing the commonly used carbon anodes for lithium-ion batteries (LIBs) due to its high specific capacity, which can be up to 11 times higher than that of carbon. However, the desirable advantage that silicon brings to battery performance is currently overshadowed by its stress-induced performance loss and high electronic resistivity. The induced stress arises from two sources, namely, the deposition process (i.

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Background: Distal sensory peripheral neuropathy (DSPN) is a complication of human immunodeficiency virus (HIV). We estimate DSPN prevalence in 7 resource-limited settings (RLSs) for combination antiretroviral therapy (cART)-naive people living with HIV (PLWH) compared with matched participants not living with HIV and in PLWH virally suppressed on 1 of 3 cART regimens.

Methods: PLWH with a CD4+ count <300 cells/mm3 underwent standardized neurological examination and functional status assessments before and every 24 weeks after starting cART.

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Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user's hand.

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Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophrenia, and bipolar disorder. Nutritional stress alters RELN expression in brain regions associated with these disorders; however, the involvement of RELN in the neural circuits involved in energy metabolism is unknown.

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Article Synopsis
  • Study examines neurocognitive impairment in HIV+ individuals despite effective antiretroviral therapy (ART), highlighting improved cognitive function after ART initiation in resource-limited countries.* -
  • The research involved a randomized clinical trial assessing cognitive performance and compared it to data from HIV-negative participants, establishing categories of neurocognitive impairment in HIV+ individuals.* -
  • Findings revealed that nearly half of the participants had some level of neurocognitive impairment at the start, but significant improvements were noted over time with ART, particularly among those with more severe impairments.*
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Article Synopsis
  • The study compared neurological and neuropsychological performance in HIV-1-infected individuals in resource-limited settings receiving three ART regimens from the World Health Organization, with a focus on the impact of tuberculosis (TB) on these outcomes.
  • Over 860 participants were analyzed, revealing that those with TB coinfection scored lower on fine motor skills tests and reported a significantly lower quality of life and productivity.
  • The findings indicate that TB coinfection negatively affects neuropsychological function and overall well-being in HIV-1-infected individuals.
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Aim: Immobilized metal ion affinity chromatography is widely employed for purifying polyhistidine-tagged recombinant proteins from cell lysates. The technique can be applied for quantification of therapeutic proteins in biological matrices by LC-MS/MS.

Results: A protein reagent-free workflow was developed for quantifying polyhistidine-tagged proteins by LC-MS/MS.

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Semiconductor (SC) quantum dots (QDs) have recently been fabricated by both chemical and plasma techniques for specific absorption and emission of light. Their optical properties are governed by the size of the QD and the chemistry of any passivation at their surface. Here, we decouple the effects of confinement and passivation by utilising DC magnetron sputtering to fabricate SC QDs in a perfluorinated polyether oil.

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Human interaction with touch screens requires physical touch and hence results in contamination of these surfaces, resulting in the necessity of cleaning. In this study we discuss the three bodies of this problem and how each component contributes and can be controlled. Utilizing a standard fingerprint machine and a standard cleanability test, this study examines the influence of parameters such as the wiping speed and pressure, the material and surface area of the cloths, and the surface energy of the contaminated surfaces.

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Irrespective of the technology, we now rely on touch to interact with devices such as smart phones, tablet computers, and control panels. As a result, touch screen technologies are frequently in contact with body grease. Hence, surface deposition arises from localized inhomogeneous finger-derived contaminants adhering to a surface, impairing the visual/optical experience of the user.

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Due to their excellent biodegradability characteristics, Mg and Mg-based alloys have become an emerging material in biomedical implants, notably for repair of bone as well as coronary arterial stents. However, the main problem with Mg-based alloys is their rapid corrosion in aggressive environments such as human bodily fluids. Previously, many approaches such as control of alloying materials, composition and surface treatments, have been attempted to regulate the corrosion rate.

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Objectives: A priority research area in minimal intervention dentistry is the characterization of the early stages of dental erosion. The aim of this in vitro study was to assess the effect of short, repetitive erosive challenges to human enamel over 2 min at pH 1.5 and 3.

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Plasma-polymerized organosilicone coatings can be used to impart abrasion resistance and barrier properties to plastic substrates such as polycarbonate. Coating rates suitable for industrial-scale deposition, up to 100 nm/s, can be achieved through the use of microwave plasma-enhanced chemical vapor deposition (PECVD), with optimal process vapors such as tetramethyldisiloxane (TMDSO) and oxygen. However, it has been found that under certain deposition conditions, such coatings are subject to post-plasma changes; crazing or cracking can occur anytime from days to months after deposition.

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Understanding species differences in the placental transfer of monoclonal antibodies is important to inform species selection for nonclinical safety assessment, interpret embryo-fetal changes observed in these studies, and extrapolate their human relevance. Data presented here for a fully human immunoglobulin G2 monoclonal antibody (IgG2X) revealed that, during organogenesis, in both the cynomolgus monkey (gestation day 35 [gd35]) and the rat (gd10) the extent of IgG2X placental transfer (approximately 0.5% maternal plasma concentration, MPC) was similar to the limited published human data for endogenous IgG.

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The characterization of variations in the chemical composition and ensuing mechanical properties across the thickness of coatings with continuously varying compositions through their thickness (graded coatings) presents considerable challenges for current analytical techniques in materials science. We report here the direct imaging of nanomechanical and chemical gradients across cross-sections of an organosilicone coating fabricated via microwave plasma enhanced chemical vapor deposition (PECVD). Cross-sectional nanoindentation was used to determine the mechanical properties of uniform and graded organosilicone coatings.

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Superhydrophobic coatings are reported as promising candidates for anti-icing applications. Various studies have shown that as well as having ultra water repellency the surfaces have reduced ice adhesion and can delay water freezing. However, the structure or texture (roughness) of the superhydrophobic surface is subject to degradation during the thermocycling or wetting process.

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Background: Development of an alternative sampling method that uses small amounts of whole blood, such as dried blood spots (DBS), would be an advance in the quantitative assay field. Previously, we assessed the ability to quantitate therapeutic monoclonal antibodies present in DBS compared with a typical serum sample-based method, and concluded that measurements in DBS were reproducible and yielded methods that met requirements for precision, accuracy and sensitivity. The goal herein was to assess the measurement of therapeutic antibodies in DBS compared with serum and plasma in vivo.

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Bioanalytical support of discovery programs for human monoclonal antibody therapies involves quantitation by immunoassay. Historically, preclinical samples have been analyzed by the traditional Enzyme-Linked Immuno-Sorbent Assay (ELISA). We investigated transferring our generic ELISA for quantitating human IgG constructs in preclinical serum samples to an automated microfluidics immunoassay platform based on nanoscale streptavidin bead columns.

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Little is known about how the prevalence and incidence of neurological disease in HIV-infected patients in resource-limited settings. We present an analysis of neurological and neurocognitive function in antiretroviral naïve individuals in multinational resource-limited settings. This prospective multinational cohort study, a substudy of a large international randomized antiretroviral treatment trial, was conducted in seven low- and middle-income countries in sub-Saharan Africa, South America, and Asia.

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