Publications by authors named "Colin Fisher"

Background: Identifying children ready for transfer out of the pediatric intensive care unit (PICU) is an area that may benefit from clinical decision support (CDS). We previously implemented a quality improvement (QI) initiative to accelerate the transfer evaluation of non-medically complex PICU patients with viral bronchiolitis receiving floor-appropriate respiratory support.

Objectives: Design a CDS tool adaptation of this QI initiative to further accelerate transfer evaluation of appropriate patients.

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Employees are often reluctant to ask for advice, despite its potential benefits. Giving employees unsolicited advice may be a way to realize the benefits of advice without relying on them to ask for it. However, for these benefits to surface, it is critical to understand employees react to unsolicited and solicited advice.

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Tobacco-specific nitrosamines (TSNAs) are carcinogens that accumulate in tobacco leaves during curing, storage, and processing, and their amounts in processed tobacco vary dependent on several intrinsic and extrinsic factors. Here, we assessed the hypothesis that there is a link between reactive oxygen species levels in leaves and TSNA formation during curing. First, we show that burley varieties KT 204LC and NCBH 129LC accumulate TSNAs to different levels but not as a result of a variety-specific abundance of TSNA precursors.

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Article Synopsis
  • Tobacco-specific nitrosamines, known carcinogens, form in freshly harvested tobacco during curing, primarily influenced by high nitrate levels.
  • The study examined the impact of microbial communities in tobacco leaves on the formation of these nitrosamines, finding strong correlations between nitrate, nitrite, and nitrosamine levels, especially under varying humidity conditions.
  • Analysis of microbial composition revealed a dominance of Proteobacteria, but an increase in Firmicutes and Actinobacteria was linked to higher nitrosamine content, suggesting potential roles of incomplete denitrification in their formation.
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Removal of terminal buds (topping) and control of the formation of axillary shoots (suckers) are common agronomic practices that significantly impact the yield and quality of various crop plants. Application of chemicals (suckercides) to plants following topping is an effective method for sucker control. However, our current knowledge of the influence of topping, and subsequent suckercide applications, to gene expression is limited.

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