Evaluation of mAb 2C5-modified dendrimer-based micelles for the co-delivery of siRNA and chemotherapeutic drug in xenograft mice model.

Combination therapy with small interfering RNA (siRNA) and chemotherapeutic drug is proven to be effective in downregulating cancer resistance proteins, such as P-glycoprotein (P-gp). These proteins are involved in multidrug resistance (MDR) of tumors. A targeted formulation capable of delivering siRNA and chemotherapeutic drug will not only downregulate P-gp but also increase the concentration of the chemotherapeutic drug at the site of tumor thereby increasing the therapeutic effect and lowering the systemic exposure.

Evaluation of mAb 2C5-modified dendrimer-based micelles for the co-delivery of siRNA and chemotherapeutic drug in xenograft mice model.

A combination therapy with small interfering RNA (siRNA) and chemotherapeutic drug is proven to be effective in downregulating the cancer resistance proteins, such as P-glycoprotein (P-gp). These proteins are involved in multidrug resistance (MDR) of tumors. MDR lowers the efficacy of chemotherapy and even renders it ineffective.

Co-Delivery of siRNA and Chemotherapeutic Drug Using 2C5 Antibody-Targeted Dendrimer-Based Mixed Micelles for Multidrug Resistant Cancers.

Multidrug resistance (MDR) observed in tumors significantly hinders the efficacy of chemotherapy. Downregulation of efflux proteins, such as P-glycoprotein (P-gp), using small interfering RNA (siRNA) can be an effective way to minimize the resistance in tumors. In this study, monoclonal antibody 2C5 (mAb 2C5)-PEG-DOPE conjugates were post-inserted into the mixed dendrimer micelles containing generation 4 (G4) polyamidoamine (PAMAM)-PEG-DOPE and PEG-DOPE.

Mixed finite elements for global tide models.

We study mixed finite element methods for the linearized rotating shallow water equations with linear drag and forcing terms. By means of a strong energy estimate for an equivalent second-order formulation for the linearized momentum, we prove long-time stability of the system without energy accumulation-the geotryptic state. A priori error estimates for the linearized momentum and free surface elevation are given in [Formula: see text] as well as for the time derivative and divergence of the linearized momentum.

Structural studies of 1,1-dimethyl-2-oxy-1-silacyclohexane by means of matrix isolation infrared absorption spectroscopy.

Infrared spectra of gaseous, liquid, and matrix-isolated samples of newly synthesized 1,1-dimethyl-2-oxy-1-silacyclohexane were recorded. Raman spectra of 1,1-dimethyl-2-oxy-1-silacyclohexane in liquid and solid states were obtained in the temperature range from 170 to 340 K. Ab initio HF and DFT B3LYP calculations were performed in order to determine the possible conformations of 1,1-dimethyl-2-oxy-1-silacyclohexane and to make accurate assignment of the vibrational spectral bands.

Data assimilation on the exponentially accurate slow manifold.

I describe an approach to data assimilation making use of an explicit map that defines a coordinate system on the slow manifold in the semi-geostrophic scaling in Lagrangian coordinates, and apply the approach to a simple toy system that has previously been proposed as a low-dimensional model for the semi-geostrophic scaling. The method can be extended to Lagrangian particle methods such as Hamiltonian particle-mesh and smooth-particle hydrodynamics applied to the rotating shallow-water equations, and many of the properties will remain for more general Eulerian methods. Making use of Hamiltonian normal-form theory, it has previously been shown that, if initial conditions for the system are chosen as image points of the map, then the fast components of the system have exponentially small magnitude for exponentially long times as ε→0, and this property is preserved if one uses a symplectic integrator for the numerical time stepping.