Premeal insulin decreases arterial stiffness in children with type 1 diabetes.

Objective: To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes.

Research Design And Methods: In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI ) were used to measure arterial stiffness. Children were randomized to receive or omit premeal insulin and completed the crossover portion of the study on a subsequent day.

Screening for T1D risk to reduce DKA is not economically viable.

Background: Children at high risk for developing type 1 diabetes (T1D) can be identified on the basis of human leukocyte antigen (HLA) genotype and the subsequent development of islet cell autoantibodies. Several studies have documented reduced incidence of diabetic ketoacidosis (DKA) in new-onset T1D when high-risk children are identified at an early age. Many have questioned whether general population screening for T1D risk should be standard of practice.