Publications by authors named "Colette Fritsche"
Wound healing is facilitated by neoangiogenesis, a complex process that is essential to tissue repair in response to injury. MicroRNAs are small, noncoding RNAs that can regulate the wound healing process including stimulation of impaired angiogenesis that is associated with type-2 diabetes (T2D). Expression of miR-409-3p was significantly increased in the nonhealing skin wounds of patients with T2D compared to the non-wounded normal skin, and in the skin of a murine model with T2D.
View Article and Find Full Text PDFAngiogenesis is critical for tissue repair following myocardial infarction (MI), which is exacerbated under insulin resistance or diabetes. MicroRNAs are regulators of angiogenesis. We examined the metabolic regulation of miR-409-3p in post-infarct angiogenesis.
View Article and Find Full Text PDFBackground: The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that readily transits back and forth between both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity.
Results: While transitioning to multicellular states, patterns of H3K4 methylation and H3K27 acetylation significantly change.
Article Synopsis
- During stress, global protein translation decreases, but certain mRNAs are still actively produced, with mechanisms behind this selectivity remaining unclear.
- METL-5 is identified as a key player that methylates a specific site on ribosomal RNA, which enhances the translation of certain mRNAs, like CYP-29A3, that produce important stress-related molecules.
- Worms with mutations in METL-5 show reduced eicosanoids and increased stress resistance, indicating that methylation of ribosomal RNA plays a crucial role in the stress response by modulating the translation of specific mRNAs.