Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: A review of the literature.

Aims: Painful diabetic peripheral neuropathy (PDPN) is a common complication of diabetes mellitus. A systematic literature review was conducted to provide an overview of published literature in the last 10-years on the epidemiology, humanistic burden and economic burden of PDPN in Europe.

Methods: A search was performed according to pre-defined strategy and review criteria in Embase, Pubmed, and conference proceedings databases from 2003 till December 2012.

WITHDRAWN: Chinese herbal medicine for atopic eczema.

This review has been withdrawn as it has been updated by way of a new protocol and then a review, as the scope of the review has substantially expanded. The citation for the new updated review is as follows: Gu S, Yang AWH, Xue CCL, Li CG, Pang C, Zhang W, Williams HC. Chinese herbal medicine for atopic eczema.

Deriving health state utilities for the numerical pain rating scale.

Background: The use of patient reported outcome measures within cost-effectiveness analysis has become commonplace. However, specific measures are required that produce values, referred to as 'utilities', that are capable of generating quality adjusted life years. One such measure - the EQ-5D - has come under criticism due to the inherent limitations of its three-level response scales.

Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring?

Well-designed clinical trials are a fundamental aspect of evidence-based medicine. Such trials are dependent on the use of valid, reliable, and relevant outcome measures. Wide variation in outcome methodology can have important detrimental effects on the correct interpretation and comparison of results.