Publications by authors named "Cole Slade"
Article Synopsis
- - Erythema multiforme (EM) is a skin condition that can occur due to infections, medications, vaccines, or autoimmune diseases, with NSAIDs like ibuprofen having rare associations with it and resultant pancytopenia (low blood cell counts).
- - A 75-year-old woman developed EM and pancytopenia after taking ibuprofen for shoulder bursitis, presenting with neck swelling, a target-shaped rash, and oral ulcers 15 days post-medication.
- - After discontinuing ibuprofen and providing supportive care, including blood transfusions, the patient’s condition improved, and she was discharged six days later, highlighting the need for awareness of rare NSAID side effects among healthcare professionals.
Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reductase (GSR) and thioredoxin reductase 2 (TXNRD2). Here, we report that loss of Idh2 accelerates age-related hearing loss, the most common form of hearing impairment, in male mice.
View Article and Find Full Text PDF