A synthetic biology approach to assemble and reboot clinically relevant tailed phages.

The rise in the frequency of antibiotic resistance has made bacterial infections, specifically , a cause for greater concern. Phage therapy is a promising solution that uses naturally isolated phages to treat bacterial infections. Ecological limitations, which stipulate a discrete host range and the inevitable evolution of resistance, may be overcome through a better understanding of phage biology and the utilization of engineered phages.