Publications by authors named "Colby Lewis V"
Objective: Studies show metformin use before and during SARS-CoV-2 infection reduces severe COVID-19 and postacute sequelae of SARS-CoV-2 (PASC) in adults. Our objective was to describe the incidence of PASC and possible associations with prevalent metformin use in adults with type 2 diabetes mellitus (T2DM).
Research Design And Methods: This is a retrospective cohort analysis using the National COVID Cohort Collaborative (N3C) and Patient-Centered Clinical Research Network (PCORnet) electronic health record (EHR) databases with an active comparator design that examined metformin-exposed individuals versus nonmetformin-exposed individuals who were taking other diabetes medications.
Article Synopsis
- Blind and deaf individuals, particularly from marginalized backgrounds, face significant health disparities and are underrepresented in precision medicine research, such as the All of Us Research Program (AoURP).
- Analysis of AoURP data from 2018-2023 reveals that blind and deaf participants, especially working-age and Asian or multi-racial individuals, are notably lacking in representation.
- This underrepresentation, particularly for Black or African American women with low education and income, raises concerns about the validity and applicability of research findings for these underserved communities.
Post-acute sequelae of SARS-CoV-2 infection (PASC) affects a wide range of organ systems among a large proportion of patients with SARS-CoV-2 infection. Although studies have identified a broad set of patient-level risk factors for PASC, little is known about the association between "exposome"-the totality of environmental exposures and the risk of PASC. Using electronic health data of patients with COVID-19 from two large clinical research networks in New York City and Florida, we identified environmental risk factors for 23 PASC symptoms and conditions from nearly 200 exposome factors.
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